Clinical Trials - Desmoid Tumor Research Foundation
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Clinical Trials

Please be aware that this page may not always be current. Updated information regarding clinical trials can be found searching for “desmoid tumor” at the National Cancer Institute’s website.

THE FOLLOWING ARE ONGOING OR RECENTLY CLOSED TRIALS INCLUDING DESMOIDS:

Compassionate Use Protocol for PF-03084014 in Patients With Advanced Solid Tumor Malignancies

Recruiting Status:

-

Last Updated:

June 16, 2017

Sponsor:

University of Colorado, Denver

ClinicalTrials.gov #:

NCT02955446

Genders:

Sexes Eligible for Study: All

Ages:

16 Years to 101 Years   (Child, Adult, Senior)

Description:

Conditions:   Neoplasm;   Desmoid Tumor
Intervention:   Drug: PF-03084014
Sponsors:   University of Colorado, Denver;   Pfizer
No longer available - verified June 2017
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Erlotinib Hydrochloride in Reducing Duodenal Polyp Burden in Patients With Familial Adenomatous Polyposis at Risk of Developing Colon Cancer

Recruiting Status:

-

Last Updated:

April 20, 2017

Sponsor:

National Cancer Institute (NCI)

ClinicalTrials.gov #:

NCT02961374

Genders:

Sexes Eligible for Study: All

Ages:

18 Years to 69 Years   (Adult, Senior)

Description:

Conditions:   Attenuated Familial Adenomatous Polyposis;   Familial Adenomatous Polyposis
Interventions:   Drug: Erlotinib Hydrochloride;   Other: Laboratory Biomarker Analysis
Sponsor:   National Cancer Institute (NCI)
Not yet recruiting - verified April 2017
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National Clinical-biological Prospective Cohort of Incident Cases of Aggressive Fibromatosis (ALTITUDES)

Recruiting Status:

-

Last Updated:

August 16, 2016

Sponsor:

Centre Oscar Lambret

ClinicalTrials.gov #:

NCT02867033

Genders:

Sexes Eligible for Study: All

Ages:

Child, Adult, Senior

Description:

Condition:   Aggressive Fibromatosis
Interventions:   Procedure: biopsy;   Other: biobank constitution;   Procedure: Coloscopy;   Procedure: Blood sampling (facultative);   Other: Pain evaluation;   Procedure: Tumor biobank realization
Sponsors:   Centre Oscar Lambret;   Ligue contre le cancer, France;   Institut Curie;   Hôpital de la Timone
Recruiting - verified August 2016
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Optional Sub-study to Intraoperative Imaging With ICG Registry

Recruiting Status:

-

Last Updated:

July 19, 2016

Sponsor:

Abramson Cancer Center of the University of Pennsylvania

ClinicalTrials.gov #:

NCT02651246

Genders:

Sexes Eligible for Study: All

Ages:

18 Years and older   (Adult, Senior)

Description:

Conditions:   Lung, Prostate, Breast, Colon, Pancreatic, Renal, Bladder,Thyroid, Ovarian, Head and Neck,GI (Foregut - Esophagus),GI (Midgut) Cancer;   Cancer of the Ovarian, Head and Neck,GI (Foregut - Esophagus),GI (Midgut), Sarcoma Cancer;   Cancer of Neuro-onc, Parathyroid, Desmoid Tumors, Melanoma Cancer
Intervention:   Other: data collection
Sponsor:   Abramson Cancer Center of the University of Pennsylvania
Recruiting - verified July 2016
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A Trial of Imatinib for Patients With Aggressive Desmoid Tumor (Aggressive Fibromatosis)

Recruiting Status:

-

Last Updated:

July 12, 2016

Sponsor:

Yonsei University

ClinicalTrials.gov #:

NCT02495519

Genders:

Sexes Eligible for Study: All

Ages:

10 Years and older   (Child, Adult, Senior)

Description:

Condition:   Fibromatosis
Intervention:   Drug: Imatinib
Sponsor:   Yonsei University
Active, not recruiting - verified July 2016
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Evaluation of the Cryodestruction of Non Abdominopelvic Desmoid Tumors in Patients Progressing Despite Medical Treatment

Recruiting Status:

-

Last Updated:

September 16, 2016

Sponsor:

University Hospital, Strasbourg, France

ClinicalTrials.gov #:

NCT02476305

Genders:

Sexes Eligible for Study: All

Ages:

18 Years and older   (Adult, Senior)

Description:

Condition:   Desmoid Tumors
Intervention:   Device: "cryoprobes"
Sponsor:   University Hospital, Strasbourg, France
Recruiting - verified September 2016
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18F-FES PET/CT in Imaging Patients With Desmoid Tumors

Recruiting Status:

-

Last Updated:

January 12, 2017

Sponsor:

Vanderbilt-Ingram Cancer Center

ClinicalTrials.gov #:

NCT02374931

Genders:

Sexes Eligible for Study: All

Ages:

18 Years and older   (Adult, Senior)

Description:

Conditions:   Deep Fibromatosis/Desmoid Tumor;   Familial Adenomatous Polyposis
Interventions:   Radiation: F-18 16 Alpha-Fluoroestradiol;   Procedure: Positron Emission Tomography;   Procedure: Computed Tomography;   Other: Laboratory Biomarker Analysis
Sponsors:   Vanderbilt-Ingram Cancer Center;   National Cancer Institute (NCI)
Recruiting - verified January 2017
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Tailored Beta-catenin Mutational Approach in Extra-abdominal Sporadic Desmoids Tumor Patients

Recruiting Status:

-

Last Updated:

September 10, 2015

Sponsor:

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

ClinicalTrials.gov #:

NCT02547831

Genders:

Sexes Eligible for Study: All

Ages:

Child, Adult, Senior

Description:

Condition:   Desmoid-type Fibromatosis
Intervention:   Other: Observational approach
Sponsors:   Fondazione IRCCS Istituto Nazionale dei Tumori, Milano;   Ministero della Salute, Italy
Recruiting - verified September 2015
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Toremifene in Desmoid Tumor: Prospective Clinical Trial and Identification of Potential Molecular Targets

Recruiting Status:

-

Last Updated:

January 30, 2015

Sponsor:

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

ClinicalTrials.gov #:

NCT02353429

Genders:

Sexes Eligible for Study: All

Ages:

18 Years and older   (Adult, Senior)

Description:

Condition:   Desmoid Type-fibromatosis
Intervention:   Drug: Toremifene
Sponsors:   Fondazione IRCCS Istituto Nazionale dei Tumori, Milano;   Associazione Italiana per la Ricerca sul Cancro
Unknown status - verified January 2015
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Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version

Recruiting Status:

-

Last Updated:

January 29, 2015

Sponsor:

michal roll

ClinicalTrials.gov #:

NCT02354560

Genders:

Sexes Eligible for Study: All

Ages:

10 Years to 17 Years   (Child)

Description:

Condition:   FAP-Familial Adenomatous Polyposis
Intervention:   Drug: Erythromycin
Sponsor:   michal roll
Not yet recruiting - verified January 2015
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Prospective Trial Comparing the Performance Profiles of Two Non-Cross-Linked Porcine Dermal Matrices in Abdominal Wall Reconstruction

Recruiting Status:

-

Last Updated:

January 14, 2017

Sponsor:

Janis, Jeffrey E, MD

ClinicalTrials.gov #:

NCT02228889

Genders:

Sexes Eligible for Study: All

Ages:

18 Years to 99 Years   (Adult, Senior)

Description:

Conditions:   Hernia, Ventral;   Intestinal Fistula;   Fibromatosis, Abdominal
Interventions:   Procedure: Abdominal wall reconstruction with Strattice;   Other: Assess pain intensity at last office visit preoperatively;   Other: Assess pain interference at last office visit preoperatively;   Other: Assess physical functioning at last office visit preoperatively;   Other: Assess patient quality of life at last office visit preoperatively;   Other: Assess patient pain intensity postoperatively;   Other: Assess pain interference postoperatively;   Other: Assess physical functioning postoperatively;   Other: Assess quality of life postoperatively;   Other: Assess hernia recurrence at 30 days postoperatively;   Other: Assess bulge at 30 days postoperatively;   Other: Assess Surgical Site Occurrences at 30 days postoperatively;   Other: Assess hernia recurrence at 1 year postoperatively;   Other: Assess bulge at 1 year postoperatively;   Other: Assess Surgical Site Occur
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Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis

Recruiting Status:

-

Last Updated:

August 17, 2017

Sponsor:

National Cancer Institute (NCI)

ClinicalTrials.gov #:

NCT02066181

Genders:

Sexes Eligible for Study: All

Ages:

18 Years and older   (Adult, Senior)

Description:

Condition:   Desmoid-Type Fibromatosis
Interventions:   Other: Laboratory Biomarker Analysis;   Other: Placebo;   Other: Quality-of-Life Assessment;   Drug: Sorafenib Tosylate
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting - verified August 2017
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MR-guided High Intensity Focused Ultrasound (HIFU) on Pediatric Solid Tumors

Recruiting Status:

-

Last Updated:

June 8, 2017

Sponsor:

AeRang Kim

ClinicalTrials.gov #:

NCT02076906

Genders:

Sexes Eligible for Study: All

Ages:

up to 30 Years   (Child, Adult)

Description:

Conditions:   Relapsed Pediatric Solid Tumors;   Refractory Pediatric Solid Tumors;   Tumors Located in Bone or Soft Tissue in Close Proximity to Bone;   Rhabdomyosarcoma;   Ewing Sarcoma;   Osteosarcoma;   Neuroblastoma;   Wilms Tumor;   Hepatic Tumor;   Germ Cell Tumor;   Desmoid Tumor
Intervention:   Device: Magnetic Resonance High Intensity Focused Ultrasound
Sponsor:   AeRang Kim
Recruiting - verified June 2017
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Phase II Trial of the Gamma-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors/Aggressive Fibromatosis

Recruiting Status:

-

Last Updated:

June 30, 2017

Sponsor:

National Cancer Institute (NCI)

ClinicalTrials.gov #:

NCT01981551

Genders:

Sexes Eligible for Study: All

Ages:

18 Years to 120 Years   (Adult, Senior)

Description:

Conditions:   Desmoid Tumors;   Aggressive Fibromatosis
Intervention:   Drug: PF-03084014
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting - verified June 21, 2017
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Safety and Efficacy Study Using 5-ALA Oral Administration as an Adjuvant Therapy on the Rate of Local Tumor Recurrence in Patients Who Have Desmoids Tumors

Recruiting Status:

-

Last Updated:

October 30, 2013

Sponsor:

michal roll

ClinicalTrials.gov #:

NCT01898416

Genders:

Sexes Eligible for Study: All

Ages:

18 Years and older   (Adult, Senior)

Description:

Conditions:   The Aim of the Study is to Evaluate the Efficacy of Photodynamic Therapy as an;   Adjuvant Therapy on the Clinical Outcome of Patients With Desmoid Tumors After;   Surgical Resection
Intervention:   Drug: 5-AMINOLEVULINIC ACID (5-ALA), is a non fluorescent prodrug.
Sponsor:   michal roll
Recruiting - verified October 2013
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Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis

Recruiting Status:

-

Last Updated:

June 25, 2014

Sponsor:

michal roll

ClinicalTrials.gov #:

NCT02175914

Genders:

Sexes Eligible for Study: All

Ages:

18 Years and older   (Adult, Senior)

Description:

Condition:   FAP-Familial Adenomatous Polyposis
Intervention:   Drug: Erythromycin
Sponsor:   michal roll
Unknown status - verified June 2014
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PAZOPANIB Efficacy and Tolerance in Desmoids Tumors

Recruiting Status:

-

Last Updated:

May 25, 2016

Sponsor:

Institut Bergonié

ClinicalTrials.gov #:

NCT01876082

Genders:

Sexes Eligible for Study: All

Ages:

18 Years and older   (Adult, Senior)

Description:

Condition:   Progressive Desmoids Tumors
Interventions:   Drug: PAZOPANIB treatment;   Drug: Active Comparator: Vinblastine and Methotrexate
Sponsor:   Institut Bergonié
Recruiting - verified May 2016
More Details

A Dose Escalation Study of OMP-54F28 in Subjects With Solid Tumors

Recruiting Status:

-

Last Updated:

July 25, 2017

Sponsor:

OncoMed Pharmaceuticals, Inc.

ClinicalTrials.gov #:

NCT01608867

Genders:

Sexes Eligible for Study: All

Ages:

18 Years to 90 Years   (Adult, Senior)

Description:

Condition:   Solid Tumors
Intervention:   Biological: OMP-54F28
Sponsors:   OncoMed Pharmaceuticals, Inc.;   Bayer
Completed - verified July 2017
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Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas

Recruiting Status:

-

Last Updated:

May 13, 2016

Sponsor:

Children's Oncology Group

ClinicalTrials.gov #:

NCT01567046

Genders:

Sexes Eligible for Study: All

Ages:

up to 30 Years   (Child, Adult)

Description:

Conditions:   Childhood Alveolar Soft-part Sarcoma;   Childhood Angiosarcoma;   Childhood Desmoplastic Small Round Cell Tumor;   Childhood Epithelioid Sarcoma;   Childhood Fibrosarcoma;   Childhood Leiomyosarcoma;   Childhood Liposarcoma;   Childhood Malignant Mesenchymoma;   Childhood Neurofibrosarcoma;   Childhood Synovial Sarcoma;   Chordoma;   Desmoid Tumor;   Metastatic Childhood Soft Tissue Sarcoma;   Nonmetastatic Childhood Soft Tissue Sarcoma;   Recurrent Childhood Soft Tissue Sarcoma
Intervention:   Other: laboratory biomarker analysis
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed - verified May 2016
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A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner Syndrome

Recruiting Status:

-

Last Updated:

January 27, 2011

Sponsor:

Triemli Hospital

ClinicalTrials.gov #:

NCT01286662

Genders:

Sexes Eligible for Study: All

Ages:

Child, Adult, Senior

Description:

Conditions:   Gardner Syndrome;   Colorectal Carcinoma;   Desmoid Tumor
Intervention:  
Sponsor:   Triemli Hospital
Completed - verified January 2011
More Details

Endoxifen in Adults With Hormone Receptor Positive Solid Tumors

Recruiting Status:

-

Last Updated:

July 6, 2017

Sponsor:

National Cancer Institute (NCI)

ClinicalTrials.gov #:

NCT01273168

Genders:

Sexes Eligible for Study: All

Ages:

18 Years to 120 Years   (Adult, Senior)

Description:

Conditions:   Hormone Receptor-Positive Breast;   Gynecologic;   Desmoid;   Hormone Receptor-Positive Neoplasms
Intervention:   Drug: Z-Endoxifen
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified April 20, 2017
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A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis

Recruiting Status:

-

Last Updated:

April 5, 2017

Sponsor:

Maine Medical Center

ClinicalTrials.gov #:

NCT01265030

Genders:

Sexes Eligible for Study: All

Ages:

up to 29 Years   (Child, Adult)

Description:

Condition:   Desmoid Tumor
Intervention:   Drug: Sirolimus
Sponsors:   Maine Medical Center;   Desmoid Tumor Research Foundation;   Pfizer
Recruiting - verified April 2017
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Study to Evaluate Imatinib in Desmoid Tumors

Recruiting Status:

-

Last Updated:

May 2, 2017

Sponsor:

Heidelberg University

ClinicalTrials.gov #:

NCT01137916

Genders:

Sexes Eligible for Study: All

Ages:

18 Years and older   (Adult, Senior)

Description:

Conditions:   Aggressive Fibromatosis;   Desmoid Tumor
Intervention:   Drug: Imatinib
Sponsors:   Heidelberg University;   Novartis
Completed - verified May 2017
More Details

Imatinib Mesylate And Cyclophosphamide In Metronomic Administration: Dose Escalation Study Of Imatinib Mesylate

Recruiting Status:

-

Last Updated:

June 6, 2012

Sponsor:

Centre Oscar Lambret

ClinicalTrials.gov #:

NCT01046487

Genders:

Sexes Eligible for Study: All

Ages:

18 Years and older   (Adult, Senior)

Description:

Condition:   Cancer
Interventions:   Drug: Imatinib mesylate, Cyclophosphamide (Dosing level 1 );   Drug: Imatinib mesylate, Cyclophosphamide (Dosing level 2);   Drug: Imatinib mesylate, Cyclophosphamide (Dosing level 3);   Procedure: Blood sampling
Sponsor:   Centre Oscar Lambret
Completed - verified June 2012
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Effect of Hydroxyurea as Treatment for Primary Desmoid Tumors

Recruiting Status:

-

Last Updated:

April 19, 2017

Sponsor:

Children's Hospital of Philadelphia

ClinicalTrials.gov #:

NCT00978146

Genders:

Sexes Eligible for Study: All

Ages:

up to 21 Years   (Child, Adult)

Description:

Conditions:   Desmoid Tumors;   Fibromatosis
Intervention:   Drug: Hydroxyurea
Sponsor:   Children's Hospital of Philadelphia
Withdrawn - verified April 2017
More Details

Imatinib in Patients With Desmoid Tumor and Chondrosarcoma

Recruiting Status:

-

Last Updated:

August 22, 2017

Sponsor:

Italian Sarcoma Group

ClinicalTrials.gov #:

NCT00928525

Genders:

Sexes Eligible for Study: All

Ages:

18 Years to 80 Years   (Adult, Senior)

Description:

Conditions:   Advanced Desmoid Tumor;   Advanced Chondrosarcoma
Intervention:   Drug: Imatinib Mesylate
Sponsor:   Italian Sarcoma Group
Active, not recruiting - verified August 2017
More Details

Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma

Recruiting Status:

-

Last Updated:

September 23, 2016

Sponsor:

Children's Oncology Group

ClinicalTrials.gov #:

NCT00919269

Genders:

Sexes Eligible for Study: All

Ages:

up to 50 Years   (Child, Adult)

Description:

Conditions:   Adult Rhabdomyosarcoma;   Childhood Desmoplastic Small Round Cell Tumor;   Chordoma;   Desmoid Tumor;   Metastatic Childhood Soft Tissue Sarcoma;   Nonmetastatic Childhood Soft Tissue Sarcoma;   Previously Treated Childhood Rhabdomyosarcoma;   Previously Untreated Childhood Rhabdomyosarcoma;   Recurrent Adult Soft Tissue Sarcoma;   Recurrent Childhood Rhabdomyosarcoma;   Recurrent Childhood Soft Tissue Sarcoma;   Stage I Adult Soft Tissue Sarcoma;   Stage II Adult Soft Tissue Sarcoma;   Stage III Adult Soft Tissue Sarcoma;   Stage IV Adult Soft Tissue Sarcoma
Interventions:   Other: biologic sample preservation procedure;   Other: laboratory biomarker analysis
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Recruiting - verified September 2016
More Details

Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain

Recruiting Status:

-

Last Updated:

January 14, 2014

Sponsor:

INSYS Therapeutics Inc

ClinicalTrials.gov #:

NCT00538850

Genders:

Sexes Eligible for Study: All

Ages:

18 Years and older   (Adult, Senior)

Description:

Condition:   Cancer
Interventions:   Drug: Fentanyl sublingual spray;   Drug: Placebo
Sponsors:   INSYS Therapeutics Inc;   National Cancer Institute (NCI)
Completed - verified January 2014
More Details

Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas

Recruiting Status:

-

Last Updated:

December 15, 2015

Sponsor:

Memorial Sloan Kettering Cancer Center

ClinicalTrials.gov #:

NCT00474994

Genders:

Sexes Eligible for Study: All

Ages:

18 Years to 120 Years   (Adult, Senior)

Description:

Conditions:   Adult Malignant Fibrous Histiocytoma of Bone;   Desmoid Tumor;   Endometrial Cancer;   Ovarian Cancer;   Sarcoma;   Small Intestine Cancer
Intervention:   Drug: sunitinib malate
Sponsors:   Memorial Sloan Kettering Cancer Center;   National Cancer Institute (NCI);   Dana-Farber Cancer Institute
Completed - verified December 2015
More Details

Imatinib Mesylate in Treating Patients With Recurrent or Refractory Fibromatosis

Recruiting Status:

-

Last Updated:

August 29, 2016

Sponsor:

UNICANCER

ClinicalTrials.gov #:

NCT00287846

Genders:

Sexes Eligible for Study: All

Ages:

18 Years to 120 Years   (Adult, Senior)

Description:

Condition:   Desmoid Tumor
Intervention:   Drug: imatinib mesylate
Sponsor:   UNICANCER
Completed - verified August 2016
More Details

Sulindac and Tamoxifen in Treating Patients With Desmoid Tumor

Recruiting Status:

-

Last Updated:

March 23, 2017

Sponsor:

Children's Oncology Group

ClinicalTrials.gov #:

NCT00068419

Genders:

Sexes Eligible for Study: All

Ages:

up to 18 Years   (Child, Adult)

Description:

Condition:   Desmoid Tumor
Interventions:   Drug: tamoxifen citrate;   Drug: sulindac;   Other: laboratory biomarker analysis
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Active, not recruiting - verified March 2017
More Details

Radiation Therapy in Treating Patients With Aggressive Fibromatoses

Recruiting Status:

-

Last Updated:

August 26, 2013

Sponsor:

European Organisation for Research and Treatment of Cancer - EORTC

ClinicalTrials.gov #:

NCT00030680

Genders:

Sexes Eligible for Study: All

Ages:

16 Years and older   (Child, Adult, Senior)

Description:

Condition:   Desmoid Tumor
Intervention:   Radiation: radiation therapy
Sponsor:   European Organisation for Research and Treatment of Cancer - EORTC
Completed - verified August 2013
More Details

MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma

Recruiting Status:

-

Last Updated:

March 14, 2012

Sponsor:

National Institutes of Health Clinical Center (CC)

ClinicalTrials.gov #:

NCT00020579

Genders:

Sexes Eligible for Study: All

Ages:

18 Years and older   (Adult, Senior)

Description:

Condition:   Cancer
Intervention:   Drug: entinostat
Sponsors:   National Institutes of Health Clinical Center (CC);   National Cancer Institute (NCI)
Completed - verified March 2012
More Details

Vinblastine and Methotrexate in Treating Children With Desmoid Tumors

Recruiting Status:

-

Last Updated:

July 24, 2014

Sponsor:

Children's Oncology Group

ClinicalTrials.gov #:

NCT00003019

Genders:

Sexes Eligible for Study: All

Ages:

up to 21 Years   (Child, Adult)

Description:

Condition:   Desmoid Tumor
Interventions:   Drug: methotrexate;   Drug: vinblastine sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI);   Children's Cancer Group
Completed - verified July 2014
More Details

Toremifene in Treating Patients With Desmoid Tumors

Recruiting Status:

-

Last Updated:

July 9, 2013

Sponsor:

Lutheran General Hospital

ClinicalTrials.gov #:

NCT00002595

Genders:

Sexes Eligible for Study: All

Ages:

16 Years and older   (Child, Adult, Senior)

Description:

Condition:   Desmoid Tumor
Interventions:   Drug: toremifene;   Procedure: conventional surgery
Sponsor:   Lutheran General Hospital
Completed - verified August 2010
More Details
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