Dr. Kelly Mercier is a DTRF grant recipient, the DTRF Natural History Study and Patient Registry Principal Investigator, a lead clinical trial scientist at bioMerieux, and an adjunct associate professor at Duke University. She specializes in designing and implementing novel diagnostic tools for clinical care. She has received grants to understand the metabolic differences between desmoid tumors and normal adjacent tissue in the same patient with Dr. Ben Alman. Dr. Mercier is passionate about desmoid tumor research and is thrilled to be able to contribute her scientific knowledge to better understand and treat desmoid tumors.
Dr. Crago is a surgeon-scientist at Memorial Sloan-Kettering Cancer Center where she serves as an Assistant Attending. As a member of the institution’s Sarcoma Disease Management Team, she is an active participant in the care of patients with desmoid fibromatosis and coordinates clinical research and basic science efforts examining the causes of desmoid formation and progression. Her research has been funded by the American Society of Clinical Oncology, the American College of Surgeons, the Kristen Ann Carr Fund, Cycle for Survival and the MSKCC SPORE in soft tissue sarcoma. Most recently she has worked to create a nomogram that uses clinical characteristics to predict outcome after surgical resection of desmoid tumors, and she is actively engaged in work characterizing genomic changes that mediate formation of desmoid tumors.
Dr. Alman is an orthopaedic clinician-scientist, whose research focuses on understanding role of developmentally important processes in pathologic and reparative process involving the musculoskeletal system. The long-term goal of his work is to use this knowledge to identify improved therapeutic approaches to orthopaedic disorders. He makes extensive use of genetically modified mice to model human disease, and has used this approach to identify new drug therapies for musculoskeletal tumors and to improve the repair process in cartilage, skin, and bone. He also works on cellular heterogeneity in sarcomas, and has identified a subpopulation of tumor initiating cells in musculoskeletal tumors. In this work, he also has identified specific cell populations that are responsible for joint and bone development. He has was recently recruited from the University of Toronto to Duke University to chair the department of orthopaedics, which was established in 2010, and includes a large musculoskeletal research component. He has half his time protected for his research work. Dr. Alman is the Principal Investigator in the DTRF-funded collaborative project, “Collaboration for a Cure: Identifying new therapeutic targets for desmoid tumors.”
Dr. Gounder is a DTRF grant recipient and is the Foundation’s Scientific Director. He is an Assistant Professor and medical oncologist at Memorial Sloan-Kettering Cancer Center specializing in the care of patients with sarcomas of soft tissue and bone and in developing new drugs in all cancers. He has a special clinical and research interest in desmoid tumors and recently showed for the first time that sorafenib is an active drug in desmoid tumors. Dr. Gounder is the Principal Investigator in a trial partially funded by DTRF studying Nexavar/ Sorafinib in desmoid tumors.
Alexander Lazar MD/PhD is a practicing academic pathologist at The University of Texas MD Anderson Cancer Center where his clinical, academic and research interests are focused on sarcoma and the genomics of solid tumors. Working within a multidisciplinary team at a high volume treatment center for desmoid tumors, over the last decade he has participated with colleagues on multiple projects involving these tumors.
Dr. Robert Maki is Professor of Medicine at the Hofstra-Northwell School of Medicine, and leader of Center for New Cancer Therapies and of the sarcoma program at Monter Cancer Center, Northwell Health, New Hyde Park, New York (Long Island). He has published more than 150 articles on sarcoma treatment and basic science research, having worked on studies related to sarcoma since 1985. He treats adults with sarcomas and related tumors, such as desmoid tumors. He has an interest in translational research and in understanding the biology that leads to this complex group of malignancies, and takes great satisfaction in participating in collaborative clinical and translational research with local, national, and international colleagues. Dr. Maki is also the Director of Translational Oncology at the Sarcoma Alliance for Research through Collaboration (SARC).
Dr. Roeland Nusse is a professor in the Department of Developmental Biology at Stanford University School of Medicine, the Virginia and Daniel K. Ludwig Professor of Cancer Research and a Howard Hughes Medical Institute Investigator. He is a member of the Institute for Stem Cell Biology and Regenerative Medicine at Stanford and the Stanford Ludwig Center for Cancer Stem Cell Research and Medicine. Dr. Nusse received his PhD from the Netherlands Cancer Institute at the University of Amsterdam in 1980. He completed postdoctoral studies at the University of California, San Francisco in 1982 working with Dr. Harold Varmus. After several years as head of the molecular biology department at the Netherlands Cancer Institute, he returned to the Bay Area and joined the Stanford medical faculty in 1990 as an associate professor of developmental biology. In 1994 he was promoted to professor. In 1997 he became associate chair of the Department of Developmental Biology, and in 1999 he was appointed as chair of the department. In 2010, he was elected as a member of the National Academy of Sciences. Dr. Nusse is also a fellow of the American Academy of Arts and Sciences and a member of the Royal Dutch Academy of Sciences.
Jean is an acknowledged leader in the effective strategies and practices of capturing patient perspective data for use in the clinical development and commercial success of new medical products. He has not only published extensively in the areas of Patient Reported Outcomes (PRO) and electronic PRO (ePRO), but also on the regulatory guidance for development and implementation of ePRO. He has worked closely with the international industry and regulatory agencies on ePRO best practices. Dr. Paty’s work is well-referenced in a wide variety of peer-reviewed journals and in numerous conferences and events, where he has presented his findings on the scientific, clinical, and regulatory implications of Clinical Outcome Assessment (COA) data collection in clinical trials.
Jean joined Quintiles from invivodata (now ERT), where he was most recently Chief Scientific and Regulatory Advisor, Outcomes. Jean has collaborated with industry and regulatory agency groups on PRO and ePRO best practices, and has partnered with invivodata Co-Founder Dr. Saul Shiffman since 1990 on the creation of real-time/real-world solutions to study patient experience. He has also held positions in the Department of Psychology at the University of Pittsburgh, PA, and the Addiction Research Foundation (Toronto, Canada). Recent publications include articles on regulations guiding development and implementation of patient reported outcomes (PRO), and electronic implementation of PROs (ePRO).
Jean has a B.S. in Psychology from the University of Toronto and an M.S. and Ph.D. in Psychology from the University of Pittsburgh.
Matt van de Rijn received his MD and PhD degrees from the University of Amsterdam, the latter based on his research at the Netherlands Cancer Institute and the DANA Farber Cancer Institute. After a postdoctoral fellowship at Stanford University he completed his residency training in surgical pathology and joined the faculty at the University of Pennsylvania. In 1998 he returned to Stanford where he is now a Professor in Pathology. His research has focused on sarcoma and he reported the first major gene expression profiling study on sarcomas in 2002. The identification of a novel translocation involving CSF1 in PVNS resulted in several ongoing clinical trials. In addition his group discovered a novel diagnostic marker for GIST (DOG1). Gene expression profiling studies also led to the investigation of the role of macrophages in leiomyosarcoma (LMS) and GIST with an opportunity to develop therapeutic targets for these tumors. In addition to his work on LMS and GIST he has performed gene expression profiling studies on Desmoid Tumors to study the biology that underlies the aggressive behavior of these tumors, to develop novel diagnostic markers and discover novel therapeutic targets. Dr. van de Rijn is Principal Investigator of the DTRF-funded study, “Next generation sequencing approach to desmoid tumors.”