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International Research Workshops

2019 DTRF International Desmoid Tumor Research Workshop

 

Save the date for the Fifth Annual DTRF International Desmoid Tumor Research Workshop in conjunction with the Annual DTRF Patient Meeting. This event will bring together a diverse group of scientists including the brightest minds in desmoid tumor research, human genetics, drug development and related fields.

 

Saturday, September 21, 2019 – Annual DTRF Patient Meeting

Sunday, September 22, 2019 – DTRF International Desmoid Tumor Research Workshop

 

These events will take place in Philadelphia, PA.

 Register here.

 

See details of past Research Workshops below:

On September 23, 2018, the DTRF hosted its fifth annual DTRF International Research Workshop.
 
The following talks were given this at the Workshop:

Benjamin Alman, MD, Professor and Chair, Department of Orthopedic Surgery, Duke University, “Collaborative research: A mouse model for desmoid tumors and collaboration for a cure.”

 

Gerlinde Wernig, MD, Assistant Professor of Pathology, Stanford University, “To study the contribution of JUN to the pathomechanism of desmoid-type fibromatosis with a particular focus on the interaction with b-catening/wnt and Notch pathways”.

 

O. Hans Iwenofu, MD, FCAP, Associate Professor, Divisions of Head & Neck Pathology and Soft Tissue & Bone Pathology, Department of Pathology, The Ohio State University, “Quantitative Proteomics Analysis of Desmoid-Type Fibromatosis.”

 

Jesse Boehm, PhD, Associate Director, Broad Cancer Program, Institute Scientist, Broad Institute, “Partnering with patients to create a desmoid tumor dependency map.”

Abstract   Presentation

Peter Hohenberger, MD, PhD, Medical Faculty, Mannheim, University of Heidelberg, Germany, “The Management of Desmoid Tumors: A joint global evidence-based consensus approach for adult and pediatric patients.” 

Abstract  Presentation

Chiara Colombo, MD, Surgical Oncologist, Fondazione IRCCS Istituto Tumori Milano, “Can Wait and See be the standard of care for initial approach to primary sporadic desmoid tumors? Preliminary data from an Italian Sarcoma Group prospective study.”

Abstract

Kris Vleminckx, PhD, Professor, Animal Disease Modeling, Ghent University, Belgium, “Identifying targets for therapy in a novel genetic Xenopus model for desmoid tumor formation.” 

Abstract    Presentation

Margaret von Mehren, MD, Director of Sarcoma Oncology, Fox Chase Cancer Center, “NCCN guidelines for desmoid tumors.”

 

Yoshihiro Nishida, MD, PhD, Rehabilitation & Orthopedic Oncology, Nagoya University Graduate School of Medicine, “Effects of uniaxial stretch forces and matrix stiffness on the cell behavior of desmoid-type fibromatosis.” 

Abstract   Presentation

Eldad Elnekave, MD, Director of Interventional Oncology Clinic, Rabin Medical Center, “Doxorubicin eluting intra-arterial therapy for pediatric extra-abdominal desmoid fibromatosis– a promising approach for a perplexing disease.”

Abstract    Presentation

Fariba Navid, MD, Associate Professor, Children’s Hospital Los Angeles, “Pediatric gamma secretase inhibitor study.”

Presentation

Jessica Foley, PhD, Chief Scientific Officer, Focused Ultrasound Foundation, “Focused Ultrasound: State of the field and potential for treating desmoid tumors.” 

Abstract   Presentation

Antoine Italiano, MD, PhD, Medical Oncologist and Head of EArly Phase Trial sand Sarcoma Units, Institut Bergonié, “Pazopanib versus IV methotrexate/vinblastine in adult patients with progressive desmoid tumors.”

Presentation

Kelly Mercier, PhD, Adjunct Associate, Duke University and Sr. Clinical Scientist at bioMerieux, “An update on the DTRF Patient Registry and National History Study.”

 

Mrinal Gounder, MD, Assistant Professor and Medical oncologist, Memorial Sloan Kettering Cancer Center, “Phase III, randomized, double blind, placebo-controlled trial of sorafenib in desmoid tumors.”

 

Raphael Pollock, MD, PhD, FACS, Professor and Director, Division of Surgical Oncology, Surgeon in Chief, James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, “RUNX3 can abrogate CTNNB1 S45F mutation impaired apoptotic responses in desmoid tumors.” 

Abstract  Presentation

Mushriq Al-Jazrawe, HBSc, PhD Candidate, University of Toronto, Laboratory Medicine & Pathobiology, “Stroma-derived secreted factors increase desmoid tumor cell proliferation.” 

Abstract  Presentation

Milea Timbergen, MD, PhD candidate, Surgical Oncology/Medical Oncology, Erasmus MC, “Mutation stratification of desmoid tumors using a radiogenomics approach.”  

Abstract   Presentation

Aaron Weiss, DO, Pediatric oncologist, Maine Medical Center, “Feasibility of pre-operative mTOR inhibitor sirolimus in children and young adults with desmoid tumor.” 

Abstract    Presentation

Joanna Przybyl, PhD, Postdoctoral Research Fellow, Department of Pathology, Stanford University, “Gene expression profiling of desmoid tumors.” 

Abstract

View bios of our 2018 presenters and attendees here.

View event photos here.

On September 24, 2017, the DTRF hosted our fourth DTRF International Research Workshop with over 50 researchers in attendance from the United States, Canada, Italy, UK, Spain, Japan, Germany, the Netherlands and Belgium.
 
The following talks were given at the Workshop.
  • David Kirsch, MD, PhD, Barbara Levine University Professor and Vice Chair for Basic & Translational Research, Department of Radiation Oncology Professor, Department of Pharmacology & Cancer Biology, Duke University, “Using radiation therapy to treat desmoid tumors.”  Abstract   |  Presentation

 

  • Tom van Cann, MD, Medical Oncologist, KU Leuven, “Systemic treatment preferences for patients with advanced desmoid-type fibromatosis in Europe.” Abstract

 

  • Milea J.M. Timbergen, MD, PhD candidate, Erasmus Medical Center, “Results of the interim analysis of the Dutch GRAFITI study.”  Abstract  |  Presentation

 

  • Breelyn Wilky, MD, Assistant Professor in Hematology/Oncology, University of Miami Sylvester Comprehensive Cancer Center, “Mutation phenotypes and their responses to chemotherapy.”  

 

  • Chiara Colombo MD, Surgical Oncology, Fondazione IRCCS- Instituto Tumori di Milano, β -catenin in Desmoid-Type Fibromatosis: deep insights on the role of T41A and S45F mutations on protein structure and gene expression.”  

 

  • Danielle Braggio, PhD, Post-Doctoral Researcher, Ohio State University, “Autophagy inhibition overcomes sorafenib resistance in S45F-mutated desmoid tumors.”  Abstract  |  Presentation

 

  • Yoshihiro Nishida, MD, PhD, Associate Professor, Nagoya University Graduate School of Medicine, “Effects of mechanical forces on the cell behavior of desmoid-type fibromatosis.”  Abstract

 

  • Kris Vleminckx, PhD, Professor, Department of Molecular Biomedical Research Unit of Developmental Biology VIB, Ghent University, “Therapeutic target identification in a Xenopus model for desmoid tumor formation – an update.”  Abstract

 

  • Gerlinde Wernig, MD, Assistant Professor of Pathology, Stanford University, “Unifying mechanism of different fibrotic diseases.”  

 

  • Sant Chawla, MD, FRACP, Medical Director, Sarcoma Oncology Research Center, “Designing new clinical trials in desmoid tumor.”  Presentation

 

  • Steve Horrigan, PhD, Chief Scientific Officer, Beta Cat Pharmaceuticals, “Tegavivint (BC2059) – A new way of attacking beta-catenin driven disease.”

 

  • Danielle Braggio, PhD, Post-Doctoral Researcher, Ohio State University, “Tegavivint (BC2059) studies in desmoid cell lines.”

 

  • Benjamin Alman, MD, Professor and Chair, Department of Orthopedic Surgery, Duke University, “Tegavivint (BC2059) studies in Apc(+)/Apc(1638N) genetic mouse model of aggressive fibromatosis.”

 

  • Casey Cunningham, MD, Chief Medical Officer, Beta Cat Pharmaceuticals, Synopsis of a Planned Phase 1/2 Study of Tegavivant (BC2059) in desmoid tumors.” Abstract

 

  • Benjamin Alman, MD, Professor and Chair, Department of Orthopedic Surgery, Duke University, “Introduction and report on Collaboration for a Cure project.”  Presentation

 

  • Kelly Mercier, PhD, Research Scientist in Metabolomics, RTI International, “A metabolomics pilot study on desmoid tumors and novel drug candidates.” Abstract  

 

  • Gary Schwartz, MD, Chief, Division of Hematology/Oncology, Columbia University, A systems biology approach to the identification of new treatments for patients with soft tissue sarcomas including desmoid tumors.”   

 

  • Aaron Weiss, DO, Assistant Clinical Professor of Pediatrics, Maine Medical Center, Development of a DTRF-sponsored virtual tumor board.” Abstract  |  Presentation

 

  • Kelly Mercier, PhD, Research Scientist in Metabolomics, RTI International, “DTRF Natural History Study and patient registry launch and update.” Abstract
 

View bios of our 2017 presenters and attendees here.

On September 25, 2016, the DTRF hosted our third DTRF International Research Workshop with over 40 researchers in attendance from the United States, Europe and Asia. The presentations below were given at the Workshop.
  • Benjamin Alman, MD, Department Chair, Orthopedic Surgery, Duke University,
    “Introduction and Report on Collaboration for a Cure project.”

 

  • Kris VleminckxPhD, Professor of Developmental Biology, Ghent University
    “Identifying targets for therapy in a novel genetic Xenopus model for desmoid tumor formation.”  Abstract

 

  • Stephen Horrigan, PhD, Chief Scientific Officer, BetaCat Pharmaceuticals
    “Tegatrabetan (BC-2059) – A new approach to targeting beta catenin and Wnt activation.”  Abstract

 

  • Danielle Braggio, PhD, Post-Doctoral Researcher, Ohio State University
    “Initial studies of Tegatrabetan (BC-2059) in desmoid tumor cell strains.”  Abstract

 

  • Mrinal Gounder, MD, Assistant Professor and Medical Oncologist, Memorial Sloan Kettering Cancer Center,
    “Development of PRO tool in desmoid tumors.”

 

  • Steven AttiaDO, Assistant Professor of Oncology, Mayo Clinic
    “A model for international, multi-institutional, multi-disciplinary sarcoma videoconferencing.”  Abstract

 

  • Nicholas Penel, MD, PhD, Medical Oncology, Centre Oscar Lambret
    “The French Patient Registry Project.”  Abstract

 

  • Danique van Broekhoven, MD, Surgical Oncology, Erasmus MC
    “Outcome of non-surgical management of extra-abdominal and abdominal desmoid-type fibromatosis: a population based study.”  Abstract

 

  • Matt van de Rijn, MD, PhD, Professor, Department of Pathology, Stanford University Medical Center,
    “Gene expression profiling of desmoid tumors.”

 

  • Danielle Braggio, PhD, Post-Doctoral Researcher, Ohio State University
    “Investigation of antitumor effects of sorafenib on desmoid tumors.”  Abstract

 

  • Lara Sullivan, MD, MBA, Vice President, Pfizer CURES, Pfizer, Inc.,
    “Update on clinical trials on Pfizer compound/ a potential new treatment.”

 

  • Peter Hohenberger, MD, Mannheim University Medical Center
    “An analysis of incidence and significance of trauma prior to desmoid tumor formation.”  Abstract

 

  • Nancy Cho, MD, Assistant Professor of Surgery, Harvard Medical School
    “Targeting hyaluronic acid in desmoid tumors.”   Abstract

 

  • Chiara Colombo, MD, Surgical Oncology, Instituto Tumori di Milano
    “Whole Exome Sequencing in patients under Wait & See (W&S): a preliminary analysis.”  Abstract

 

  • Daniela SegatPhD, Senior Researcher, ”Mauro Baschirotto” Institute for Rare Diseases – B.I.R.D. Foundation,
    “In vitro studies of the microenvironmental factors responsible of the proliferation and aggressiveness of desmoid tumor cells.”  Abstract  |  Presentation

View bios of our 2016 presenters and attendees here.

On October 18, 2015, we held our second DTRF International Research Workshop with over 40 researchers in attendance from the United States, Europe and Asia. View abstracts of the following presentations here.
  • Benjamin Alman, MD, Department Chair, Orthopedic Surgery, Duke University, Introduction and Report on Collaboration for a Cure project.

 

  • Alexander Lazar, MD, PhD, Director, Department of Pathology, MD Anderson Cancer Center Selective (Soft Tissue) Pathology Fellowship Training Program, “CTNNB1 Genotyping in Desmoid Tumors: Where Do We Stand?”

 

  • Danielle Braggio, PhD, Post-Doctoral Researcher, Ohio State University, “Reactivation of apoptosis as a potential therapeutic target for desmoid tumors with CTNNB1 S45F mutation.”

 

  • Radhika Atit, PhD, Associate Professor, Case Western Reserve University Dept of Biology, Case Western Reserve University, “Sustained β-catenin activity in dermal fibroblasts promotes fibrosis by regulating extracellular matrix protein-coding genes.”

 

  • Meredith K. Chuk, MD, Scientific Liaison for Sarcoma, Medical Officer, FDA, “A review of FDA draft guidance–Rare Diseases: Common Issues in Drug Development.”

 

  • Yoshihiro Nishida, MD, PhD, Chairperson, Associate Professor Dept. of Orthopaedic Surgery, Nagoya University, “Planned simple resection for selected patients with extra-peritoneal desmoid tumors.”

 

  • Alice Chen, MD, Investigational Drug Branch, NCI- NIH, “Phase II trial of PF-03084014 in adults with desmoid tumors/aggressive fibromatosis.”

 

  • Raphael Pollock, MD, PhD, Professor of Surgery; Director, Division of Surgical Oncology, Ohio State University Comprehensive Cancer Center, “Targeting the Notch Pathway: A Potential Therapeutic Approach for Desmoid Tumors.”

 

  • Mrinal Gounder, MD, Assistant Professor and Medical Oncologist at Memorial Sloan Kettering Cancer Center, Notch Inhibition in Desmoids: “Sure It Works in Practice, but Does it Work in Theory?”

 

  • Bernd Kasper, MD, PhD, Professor, Mannheim University Medical Center, Interdisciplinary Tumor Center, Sarcoma Unit, “Clinical and translational research results of a phase II study evaluating imatimib to induce progression arrest in RECIST progressive desmoid-type fibromatosis – A study of the German Interdisciplinary Sarcoma Group (GISG-01).”

 

  • Mushriq Al-Jazrawe, PhD Candidate, University of Toronto, Laboratory Medicine & Pathobiology, “Single cell-derived clonal analysis of desmoid tumors.”

 

  • Kelly Mercier, PhD, Research Chemist, Systems and Translational Science, NIH, Eastern Regional Comprehensive Metabolomics Core (RTI RCMRC), “Metabolomics: Moving Towards A Better Understanding of Desmoid Tumors.”

 

  • Ty Subhawong, MD, Musculoskeletal Radiology, Assistant Professor of Radiology University of Miami, “MRI features of response in systemic therapy for aggressive fibromatosis.”
View bios of our presenters and attendees here.
On September 28, 2014, we held our first DTRF International Research Workshop with over 20 researchers in attendance from the United States and Europe. It was a diverse group of scientists, including experts in desmoid tumor research, human genetics, drug development and related fields.

 

We had short presentations on the current state of desmoid tumor research, and devoted several hours to collaborative group discussions where we asked the important questions: What are the gaps in knowledge that we need to address next? How can we collaborate to move the science forward most efficiently, using the limited resources available? There were offers to pool resources and information, and ideas generated for new collaborative research. This is a hands-on workshop that produces practical results. We are excited to already have three projects that are being formulated to address very specific issues raised in the workshop.

 

The following institutions were represented at the 2014 Research Workshop:
  • Brigham & Women’s Hospital
  • Duke University
  • Fondazione IRCCS Istituto Nazionale dei Tumori
  • Lunenfeld-Tanenbaum Research Institute
  • MD Anderson Cancer Center
  • Memorial Sloan-Kettering Cancer Center
  • Mount Sinai Hospital, Toronto
  • National Cancer Institute (NCI)
  • National Institutes of Health (NIH)
  • Netherlands Cancer Institute
  • Ohio State Comprehensive Cancer Center
  • Stanford University
  • University of Miami
  • University of Toronto
  • U.S. Food and Drug Administration (FDA)
  • Vanderbilt University
  • Wake Forest University
View our Research Workshop pictures here.
 
View bios of our presenters and attendees here.
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