New onset hidradenitis suppurativa and eruptive milia associated with gamma secretase inhibitor therapy in a patient with desmoid tumor: A case report

Summary

Hidradenitis suppurativa (HS) is a chronic inflammatory disorder that predominantly affects intertriginous sites such as the axillae, inframammary folds, inguinal, and gluteal regions. It is characterized by recurrent nodules, abscesses, and draining tunnels that often lead to irreversible scarring. The etiology of HS is believed to be multifactorial and likely involves a combination of follicular occlusion, genetic factors, hormonal influences, and immune dysregulation.1 Recent literature suggests that mutations in the gamma secretase (GS) complex may play a role in driving HS in certain patient subpopulations.2 Herein, we present a case of a patient who developed new-onset HS-like nodules, draining abscesses, and eruptive milia following the use of a GS inhibitor.