Join us in Philadelphia from Sept. 25-27th for our "Together We Will" Weekend: - Register today!

The Desmoid Tumor Research Foundation

March 2025

Outcomes of Intestinal Transplantation for Familial Adenomatous Polyposis Associated Intraabdominal Desmoid Disease

Author Information

Mohamed Elshawy 1, Nicholas Smith 2, Joshua Sommovilla 3, Carole A Burke 4, Anil Vaidya 5, Carole Macaron 6, David Liska 7

Department of Colorectal Surgery; Digestive Disease Institute, Cleveland Clinic, Ohio, USA; The Sanford R. Weiss Center for Hereditary Colorectal Neoplasia, Digestive Disease Institute, Cleveland Clinic, Ohio, USA; General Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address: drmohamedelemam@med.asu.edu.eg.2The Sanford R. Weiss Center for Hereditary Colorectal Neoplasia, Digestive Disease Institute, Cleveland Clinic, Ohio, USA. Electronic address: nicholas134@hotmail.com.3Department of Colorectal Surgery; Digestive Disease Institute, Cleveland Clinic, Ohio, USA; The Sanford R. Weiss Center for Hereditary Colorectal Neoplasia, Digestive Disease Institute, Cleveland Clinic, Ohio, USA. Electronic address: sommovj@ccf.org.4Department of Colorectal Surgery; Digestive Disease Institute, Cleveland Clinic, Ohio, USA; The Sanford R. Weiss Center for Hereditary Colorectal Neoplasia, Digestive Disease Institute, Cleveland Clinic, Ohio, USA; Department of Gastroenterology, Hepatology, Nutrition, Digestive Disease Institute, Cleveland Clinic, Ohio, USA. Electronic address: burkec1@ccf.org.5The Sanford R. Weiss Center for Hereditary Colorectal Neoplasia, Digestive Disease Institute, Cleveland Clinic, Ohio, USA; Center for Gut Rehabilitation and Transplantation, Digestive Disease Institute, Cleveland Clinic, Ohio, USA. Electronic address: vaidya.ac@gmail.com.6The Sanford R. Weiss Center for Hereditary Colorectal Neoplasia, Digestive Disease Institute, Cleveland Clinic, Ohio, USA; Department of Gastroenterology, Hepatology, Nutrition, Digestive Disease Institute, Cleveland Clinic, Ohio, USA. Electronic address: macaroc@ccf.org.7Department of Colorectal Surgery; Digestive Disease Institute, Cleveland Clinic, Ohio, USA; The Sanford R. Weiss Center for Hereditary Colorectal Neoplasia, Digestive Disease Institute, Cleveland Clinic, Ohio, USA. Electronic address: liskad@ccf.org.

Publication

J Gastrointest Surg

Summary

Approximately 15% of familial adenomatous polyposis (FAP) patients develop desmoid tumors with 40% intra-abdominal desmoids (IAD) which contribute to significant morbidity and mortality due to bowel obstruction, fistulization, sepsis, abdominal bleeding, and/or ureteral obstruction. [1] IADs can lead to intestinal failure (IF), necessitating total parenteral nutrition (TPN) and risk of line sepsis, and intestinal failure-associated liver disease. [2], [3] Although intestinal transplantation (ITx) offers a potential salvage option, there is paucity of data on long-term outcomes and survival in this patient population.

View Abstract