The Desmoid Tumor Research Foundation

July 2023

Predictive value of micro-RNA expression profiling in pediatric desmoid fibromatosis

Author Information

Mohamed Eid 1, Hanafy Hafez 1 2, Hend E El-Shaqanqery 3, Omar Samir 3, Inas El Nadi 1 4, Madeeha Elwakeel 5, Asmaa Salama 6, Alaa Younes 7, Gehad Ahmed 8, Nouran Yasser 9, Mark W Kieran 1, Ahmed Sayed 3, Alaa El Haddad 1 2

1Department of Pediatric Oncology, Children's Cancer Hospital Egypt (CCHE 57357), Cairo, Egypt. 2Department of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo, Egypt. 3Genomics Department, Children's Cancer Hospital Egypt (CCHE 57357), Cairo, Egypt. 4Department of Medical Oncology, Beni-Swef University, Cairo, Egypt. 5Department of Diagnostic Radiology, Children's Cancer Hospital Egypt (CCHE 57357), National Cancer Institute Cairo University, Cairo, Egypt. 6Department of Surgical Pathology, National Cancer Institute, Children's Cancer Hospital Egypt (CCHE 57357), Cairo University, Cairo, Egypt. 7Surgical Oncology Department, Children's Cancer Hospital Egypt (CCHE 57357), National Cancer Institute, Cairo University, Cairo, Egypt. 8Surgical Oncology Department, Surgery Department, Children's Cancer Hospital, Egypt (CCHE), Helwan University, Cairo, Egypt. 9Biostatistician - Clinical Research Department, Children's Cancer Hospital Egypt (CCHE), Cairo, Egypt.

Publication

Acta Oncol

Summary

Treating pediatric desmoid fibromatosis (DF) remains a challenge due to its unpredictable nature and potential morbidity associated with aggressive treatments. A wait-and-see approach is becoming acceptable for some cases. But, clinical predictors of prognosis are uncertain, and tumor location and size do not always correlate with disease behavior. This study explored miRNA expression patterns in DF tumors to predict their clinical behavior. Five miRNAs showed potential value in predicting DF behavior, but further validation through larger multi-institutional studies and prospective clinical trials is needed. The rarity of pediatric DF poses a limitation in obtaining a substantial sample size for analysis.

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