External Conference Posters and Abstracts

2026 | ESMO Sarcoma and Rare Cancers Congres

Efficacy of Nirogacestat in Improving Emotional Outcomes in Adults With Desmoid Tumors: Post Hoc Analysis From the DeFi Trial

Author: Charlotte Benson, Royal Marsden NHS Foundation Trust, London, UK

Co-Author: Bernd Kasper, University of Heidelberg, Mannheim University Medical Center, Mannheim, Germany

Co-Author: Ravin Ratan, University of Texas, MD Anderson Cancer Center, Department of Sarcoma Medical Oncology, Division of Cancer Medicine, Houston, TX, USA

Co-Author: Thierry Alcindor, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

Co-Author: Bruno Vincenzi, University of Rome Bio-Medico, Via Álvaro del Portillo, Rome, Italy

Co-Author: Chetna Bhattacharyya, SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Co-Author: Timothy Bell, SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Co-Author: Rachel Cohen, SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Co-Author: Yucheng Chu, Sumptuous Data Sciences, Monmouth Junction, NJ, USA

Co-Author: Mrinal Gounder, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA

2026 | ESMO Sarcoma and Rare Cancers Congres

Nirogacestat Pediatric Compassionate Use Program: Cross-Sectional Data Review

Author: Bernadette Brennan, Royal Manchester Children’s Hospital, Manchester, UK

Co-Author: Kelly Vallance, Cook Children’s Medical Center, Fort Worth, TX, USA

Co-Author: Ana B. Oton, SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Co-Author: Sue Scott, SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Co-Author: Alex Soyars, SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Co-Author: Waseem Alhushki, Cure 4 The Kids Foundation, Las Vegas, NV, USA

2026 | ESMO Sarcoma and Rare Cancers Congres

Efficacy of Nirogacestat in Improving Sleep Outcomes in Adults With Desmoid Tumors: Post Hoc Analysis From the DeFi Trial

Author: Bernd Kasper, University of Heidelberg, Mannheim University Medical Center, Mannheim, Germany

Co-Author: Charlotte Benson, Royal Marsden NHS Foundation Trust, London, UK

Co-Author: Ravin Ratan, University of Texas, MD Anderson Cancer Center, Department of Sarcoma Medical Oncology, Division of Cancer Medicine, Houston, TX, USA

Co-Author: Thierry Alcindor, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

Co-Author: Bruno Vincenzi, University of Rome Bio-Medico, Via Álvaro del Portillo, Rome, Italy

Co-Author: Chetna Bhattacharyya, SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Co-Author: Timothy Bell, SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Co-Author: Rachel Cohen, SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Co-Author: Yucheng Chu, Sumptuous Data Sciences, Monmouth Junction, NJ, USA

Co-Author: Mrinal Gounder, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA

2025 | CTOS Annual Meeting

Identification of patients with desmoid fibromatosis for active treatment: Results from an international multicentric prospective observational study (oral presentation)

Author: Chiara Colombo, MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy

Co-Author: Gabriele Tinè, MSc, Fondazione IRCCS Istituto Nazionale dei Tumori, Mialno, Milan, Lombardia, Italy

Co-Author: Stefanie N. Hakkesteegt, MD, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Co-Author: Dario Callegaro, MD, Fondazione IRCCS IStituto Nazionale dei Tumori, Milan, Italy, Milan, Lombardia, Italy

Co-Author: Marco Fiore, MD, FACS, FEBS, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Lombardia, Italy

Co-Author: Alessia Garavagllia, MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy

Co-Author: Rosalba Miceli, MD, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Milano, Lombardia, Italy

Co-Author: Silvia Stacchiotti, MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy

Co-Author: Elena Palassini, MD, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Lombardia, Italy

Co-Author: C. Verhoef, MD, PhD, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Co-Author: Alessandro Gronchi, MD, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Milano, Lombardia, Italy

2025 | CTOS Annual Meeting

Longterm Burden of Disease and Living Situation in Desmoid Patients – A Non-Interventional Study (oral presentation)

Author: Peter Hohenberger, MD, Mannheim University Medical Center, Mannheim, Baden-Wurttemberg, Germany

Co-Author: Martin Eichler, MSc, PhD, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Sachsen, Germany

Co-Author: Sergio Armando Zapata Bonilla, MD, Clinic for Internal Medicine III, University Cancer Center, University Hospital Mainz, Mainz, Rheinland-Pfalz, Germany

Co-Author: Franka Menge, MD, Sarcoma Unit, Department of Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Wurttemberg, Germany

Co-Author: Rebekka Hoffmann, MSc, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany, Dresden, Sachsen, Germany

Co-Author: Christina Baumgarten, SOS-Desmoid, e.V., SPAEN Sarcoma Patients EuroNet e.V, Wölfersheim, Hessen, Germany

Co-Author: Markus Schuler, MD, PhD, Faculty of Medicine, University Hospital Carl Gustav Carus, TU Dresden, Germany, Dresden, Sachsen, Germany

Co-Author: Jens Jakob, MD, Sarcoma Unit, Department of Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Wurttemberg, Germany

2025 | CTOS Annual Meeting

Predicting Failure of Active Surveillance in Desmoid-Type Fibromatosis Using Radiomics: An International Multi-Center Study (oral presentation)

Author: Stefanie N. Hakkesteegt, MD, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Co-Author: Rashmi Chugh, MD, University of Michigan, Ann Arbor, MI, USA

Co-Author: Douwe J.J. Spaanderman, MSc, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Co-Author: Chiara Colombo, MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy

Co-Author: A.R.W.W. Schut, MD, PhD, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Co-Author: Andrea Vanzulli, MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy

Co-Author: Francesco Barretta, PhD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy

Co-Author: Carlo Morosi, MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy

Co-Author: Marco Fiore, MD, FACS, FEBS, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy

Co-Author: Peter C. Ferguson, MD, MSc, FRCSC, Department of Surgery, Sinai Health, Toronto, ON, Canada

Co-Author: Harini Suraweera, MSc, Princess Margaret Cancer Centre, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada

Co-Author: Anthony M. Griffin, MSc, Orthopaedic Surgery, Sinai Health, Toronto, ON, Canada

Co-Author: Lawrence M. White, MD, Mount Sinai Health, Toronto, ON, Canada

Co-Author: Joel Shapiro, MD, PhD, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Co-Author: Danchen Ge, MSc, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Co-Author: D.J.J. Grunhagen, N/A, MD, PhD, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Co-Author: Arno J. van Leenders, MD, PhD, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Co-Author: David Hanff, MD, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Co-Author: Jan Jaap J. Visser, MD, PhD, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Co-Author: Wiro Niessen, PhD, UMC Groningen, Groningen, Groningen, Netherlands

Co-Author: Stefan Klein, PhD, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Co-Author: Rebecca Gladdy, MD, PhD, Mount Sinai Hospital, Toronto, ON, Canada

Co-Author: Alessandro Gronchi, MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Lombardia, Italy

Co-Author: Martijn P.A. Starmans, PhD, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

Co-Author: C. Verhoef, MD, PhD, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands

2025 | CTOS Annual Meeting

Subgroup Analysis of the Phase 2 Part of the Ringside Phase 2/3 Trial of Varegacestat for Treatment of Desmoid Tumors

Author: Nam Bui, MD, Stanford Health Care, Stanford, CA USA

Co-Author: Rashmi Chugh, MD, University of Michigan, Ann Arbor, MI, USA

Co-Author: Mrinal Gounder, MD, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Co-Author: Arun Singh, MD, University of California Los Angeles, Los Angeles, CA, USA

Co-Author: Vladimir Andelkovic, MD, Princess Alexandra Hospital and Icon Cancer Centre, South Brisbane, Australia

Co-Author: Janet Yoon, MD, City of Hope Comprehensive Cancer Center, Duarte, CA, USA

Co-Author: Edwin Choy, MD, PhD, Massachusetts General Hospital, Boston, MA, USA

Co-Author: Jeremy Lewin, MBBS, Peter MacCallum Cancer Centre, Victoria, Australia

Co-Author: Javier Martin-Broto, MD, PhD, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain

Co-Author: Ravin Ratan, MD, University of Texas MD Anderson Cancer Center, Houston, TX, USA

Co-Author: Winette van der Graaf, MD, PhD, Netherlands Cancer Institute, Amsterdam, The Netherlands

Co-Author: Lara Davis, MD, Oregon Health & Science University, Portland, OR, USA

Co-Author: Atrayee Basu Mallick, MD, Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, PA, USA

Co-Author: HyoSong Kim, Yonsei University College of Medicine, Seoul, Republic of Korea

Co-Author: Elizabeth T. Loggers, MD, Fred Hutchinson Cancer Center and University of Washington, Seattle, WA, USA

Co-Author: Robin L. Jones, MD, The Royal Marsden NHS Foundation Trust + Institute of Cancer Research, London, UK

Co-Author: Matthew Birrenkott, PharmD, Immunome, Bothell, WA, USA

Co-Author: Eric Song, PhD, Immunome, Bothell, WA, USA

Co-Author: Kathryn Newhall, PhD, Immunome, Bothell, WA, USA

Co-Author: Jonathan Yovell, MD, Immunome, Bothell, WA, USA

Co-Author: Bernd Kasper, MD, PhD, Mannheim University Medical Center, Mannheim, Germany

Co-Author: Brian A. Van Tine, MD, PhD, Washington University School of Medicine, St. Louis, MO, USA

2025 | CTOS Annual Meeting

Analysis of Changes in T2-Weighted Signal Intensity and Tumor Volume and Exposure-response in the RINGSIDE Phase 2 Study of Varegacestat with Desmoid Tumors

Author: Arun Singh, MD, University of California Los Angeles, Los Angeles, CA, USA

Co-Author: Mrinal Gounder, MD, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Co-Author: Rashmi Chugh, MD, University of Michigan, Ann Arbor, MI, USA

Co-Author: Bernd Kasper, MD, PhD, Mannheim University Medical Center, Mannheim, Germany

Co-Author: Brian A. Van Tine, MD, PhD, Washington University School of Medicine, St. Louis, MO, USA

Co-Author: Vladimir Andelkovic, MD, Princess Alexandra Hospital and Icon Cancer Centre, South Brisbane, Australia

Co-Author: Janet Yoon, MD, City of Hope Comprehensive Cancer Center, Duarte, CA, USA

Co-Author: Edwin Choy, MD, PhD, Massachusetts General Hospital, Boston, MA, USA

Co-Author: Jeremy Lewin, MBBS, Peter MacCallum Cancer Centre, Victoria, Australia

Co-Author: Javier Martin-Broto, MD, PhD, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain

Co-Author: Nam Bui, MD, Stanford Health Care, Stanford, CA USA

Co-Author: Winette van der Graaf, MD, PhD, Netherlands Cancer Institute, Amsterdam, The Netherlands

Co-Author: Lara Davis, MD, Oregon Health & Science University, Portland, OR, USA

Co-Author: Atrayee Basu Mallick, MD, Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, PA, USA

Co-Author: HyoSong Kim, Yonsei University College of Medicine, Seoul, Republic of Korea

Co-Author: Elizabeth T. Loggers, MD, Fred Hutchinson Cancer Center, Seattle, WA, USA

Co-Author: Matthew Birrenkott, Immunome, Bothell, WA, USA

Co-Author: Eric Song, PhD, Immunome, Bothell, WA, USA

Co-Author: Gerald Fetterly, PhD, Immunome, Bothell, WA, USA

Co-Author: Jonathan Yovell, MD, Immunome, Bothell, WA, USA

Co-Author: Robin L. Jones, MD, The Royal Marsden NHS Foundation Trust + Institute of Cancer Research, London, UK

Co-Author: Ravin Ratan, MD, University of Texas MD Anderson Cancer Center, Houston, TX, USA

2025 | CTOS Annual Meeting

Trends in the Management of Desmoid Tumors in the Veterans Affairs (VA) National Database

Sarah E. Lindsay, MD, OHSU Department of Orthopaedics & Rehabilitation, USA

Cecelia Madison, MS, Portland VA Medical Center Operative Care Division, USA

Brad Tumminello, PharmD, SpringWorks Therapeutics Inc., USA (at time of analysis)

Dipam Doshi, PharmD, SpringWorks Therapeutics Inc., USA

Susan Scott, MSN, SpringWorks Therapeutics Inc., USA

Tim Bell, MHA, SpringWorks Therapeutics Inc., USA

Duncan Ramsey, MD, MS, OHSU Department of Orthopaedics & Rehabilitation, USA

Yee-Cheen Doung MD, OHSU Department of Orthopaedics & Rehabilitation, USA

Kenneth R. Gundle, MD, OHSU Department of Orthopaedics & Rehabilitation and Portland VA Medical Center Operative Care Division, USA

2025 | CTOS Annual Meeting

Development of an Algorithm to Identify Patients with Desmoid Tumors in a United States Claims Dataset

Chia Jie Tan, College of Pharmacy, College of Pharmacy, University of Utah, Salt Lake City, UT, United States

Connor Willis, College of Pharmacy, University of Utah, Salt Lake City, UT, United States

Timothy Bell, Former employee of SpringWorks Therapeutics, Inc., Stamford, CT, United States

Brad Tumminello, SpringWorks Therapeutics, Inc., Stamford, CT, United States

Shengfan Zhou, SpringWorks Therapeutics, Inc., Stamford, CT, United States

Dipam Doshi, SpringWorks Therapeutics, Inc., Stamford, CT, United States

Carl Asche, College of Pharmacy, University of Utah, Salt Lake City, UT, United States

Joe Biskupiak, College of Pharmacy, University of Utah, Salt Lake City, UT, United States

Diana Brixner, College of Pharmacy, University of Utah, Salt Lake City, UT, United States

Anna Chalmers, Huntsman Cancer Institute, University of Utah Health, Salt Lake City, UT, United States

David Stenehjem, College of Pharmacy and College of Pharmacy, University of Utah, Salt Lake City, UT, College of Pharmacy, University of Minnesota, Duluth, MN, United States

2025 | CTOS Annual Meeting

Assessment of Pain Diagnosis and Pain Medication Use in Adults Treated With Nirogacestat: A United States Real-World Analysis

Shengfan Zhou, MS, SpringWorks Therapeutics, Inc., Stamford, CT

Eileen Farrelly, MPH, Cencora, Inc., Conshohocken, PA, USA

Shahla Amin, MS, Cencora, Inc., Conshohocken, PA, USA

Brad Tumminello, PharmD, SpringWorks Therapeutics, Inc., Stamford, CT (at time of analysis)

Timothy Bell, MHA, SpringWorks Therapeutics, Inc., Stamford, CT

2025 | CTOS Annual Meeting

A phase 1/2 trial of FOG-001, a first-in-class direct β-catenin:TCF inhibitor safety and preliminary antitumor activity in patients with desmoid tumors

Gregory M. Cote, Massachusetts General Cancer Center, Boston, MA, USA

Michael Cecchini, Yale University School of Medicine, New Haven, CT, USA

Kyriakos P. Papadopoulos, START San Antonio, San Antonio, TX, USA

Moh’d Khushman, Washington University School of Medicine, St. Louis, MO, USA

Meredith Pelster, Sarah Cannon Research Institute, Nashville, TN, USA

Jordi Rodon, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Shivaani Kummar, Oregon Health and Science University, Portland, OR, USA

Rona Yaeger, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Sunil Sharma, Honor Health, Scottsdale, AZ, USA

Amber L. Wells, Parabilis Medicines, Cambridge, MA, USA

Megan Tipps, Parabilis Medicines, Cambridge, MA, USA

Jonathan Rojo, Parabilis Medicines, Cambridge, MA, USA

Amanda Garofalo, Parabilis Medicines, Cambridge, MA, USA

Lalith Akella, Parabilis Medicines, Cambridge, MA, USA

Ziyang Yu, Parabilis Medicines, Cambridge, MA, USA

Xinwei Han, Parabilis Medicines, Cambridge, MA, USA

Laura Strong, Parabilis Medicines, Cambridge, MA, USA

Jorge D. Ramos, Parabilis Medicines, Cambridge, MA, USA

Marie Huong Nguyen, Parabilis Medicines, Cambridge, MA, USA

Keith Orford, Tagworks Pharmaceuticals, Doylestown, PA, USA

Samuel J. Klempner, Massachusetts General Cancer Center, Boston, MA, USA

2025 | ISPOR

An Assessment of Financial Burden and Its Association With Desmoid Tumor Specific Symptoms and Impact in Adult Patients With Desmoid Tumors: Desmoid Tumor Research Foundation Natural History Study

Author: Shengfan Zhou, SpringWorks Therapeutics, Inc., Stamford, CT, USA

Co-Author: Amanda Lucas, Desmoid Tumor Research Foundation, Woodcliff Lake, NJ, USA

Co-Author: Lynne Hernandez, Desmoid Tumor Research Foundation, Woodcliff Lake, NJ, USA

Co-Author: Yucheng Chu, Sumptuous Data Sciences, Monmouth Junction, NJ, US

Co-Author: Timothy Bell, SpringWorks Therapeutics, Inc., Stamford, CT, USA

Co-Author: Ana B. Oton, SpringWorks Therapeutics, Inc., Stamford, CT, USA

Co-Author: Kelly Mercier, Desmoid Tumor Research Foundation, Woodcliff Lake, NJ, Duke University, Durham, NC, USA

2025 | ASCO Annual Meeting

Change in T2-Weighted Signal Intensity, Change in Tumor Volume, and Exposure-Response Analysis in the RINGSIDE Phase 2 Study of Varegacestat in Patients with Desmoid Tumors

Author: Mrinal Gounder, MD, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Co-Author: Bernd Kasper, MD, PhD, Mannheim University Medical Center, Mannheim, Germany

Co-Author: Rashmi Chugh, MD, University of Michigan, Ann Arbor, MI, USA

Co-Author: Arun Singh, MD, University of California Los Angeles, Los Angeles, CA, USA

Co-Author: Brian A. Van Tine, MD, PhD, Washington University School of Medicine, St. Louis, MO, USA

Co-Author: Vladimir Andelkovic, MD, Princess Alexandra Hospital and Icon Cancer Centre, South Brisbane, Australia

Co-Author: Janet Yoon, MD, City of Hope Comprehensive Cancer Center, Duarte, CA, USA

Co-Author: Edwin Choy, MD, PhD, Massachusetts General Hospital, Boston, MA, USA

Co-Author: Jeremy Lewin, MBBS, Peter MacCallum Cancer Centre, Victoria, Australia

Co-Author: Javier Martin-Broto, MD, PhD, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain

Co-Author: Ravin Ratan, MD, University of Texas MD Anderson Cancer Center, Houston, TX, USA

Co-Author: Nam Bui, MD, Stanford Health Care, Stanford, CA USA

Co-Author: Winette van der Graaf, MD, PhD, Netherlands Cancer Institute, Amsterdam, The Netherlands

Co-Author: Lara Davis, MD, Oregon Health & Science University, Portland, OR, USA

Co-Author: Atrayee Basu Mallick, MD, Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, PA, USA

Co-Author: HyoSong Kim, Yonsei University College of Medicine, Seoul, Republic of Korea

Co-Author: Eric Song, PhD, Immunome, Bothell, WA, USA

Co-Author: Gerald Fetterly, PhD, Immunome, Bothell, WA, USA

Co-Author: Jonathan Yovell, MD, Immunome, Bothell, WA, USA

Co-Author: Robin L. Jones, MD, The Royal Marsden NHS Foundation Trust + Institute of Cancer Research, London, UK

2025 | ASCO Annual Meeting

Subgroup Analysis of the Phase 2 Part of the RINGSIDE Phase 2/3 Trial of Varegacestat for Treatment of Desmoid Tumors

Author: Rashmi Chugh, MD, University of Michigan, Ann Arbor, MI, USA

Co-Author: Mrinal Gounder, MD, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Co-Author: Arun Singh, MD, University of California Los Angeles, Los Angeles, CA, USA

Co-Author: Brian A. Van Tine, MD, PhD, Washington University School of Medicine, St. Louis, MO, USA

Co-Author: Vladimir Andelkovic, MD, Princess Alexandra Hospital and Icon Cancer Centre, South Brisbane, Australia

Co-Author: Janet Yoon, MD, City of Hope Comprehensive Cancer Center, Duarte, CA, USA

Co-Author: Edwin Choy, MD, PhD, Massachusetts General Hospital, Boston, MA, USA

Co-Author: Jeremy Lewin, MBBS, Peter MacCallum Cancer Centre, Victoria, Australia

Co-Author: Javier Martin-Broto, MD, PhD, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain

Co-Author: Ravin Ratan, MD, University of Texas MD Anderson Cancer Center, Houston, TX, USA

Co-Author: Nam Bui, MD, Stanford Health Care, Stanford, CA USA

Co-Author: Winette van der Graaf, MD, PhD, Netherlands Cancer Institute, Amsterdam, The Netherlands

Co-Author: Lara Davis, MD, Oregon Health & Science University, Portland, OR, USA

Co-Author: Atrayee Basu Mallick, MD, Thomas Jefferson University Sidney Kimmel Medical College, Philadelphia, PA, USA

Co-Author: HyoSong Kim, Yonsei University College of Medicine, Seoul, Republic of Korea

Co-Author: Robin L. Jones, MD, The Royal Marsden NHS Foundation Trust + Institute of Cancer Research, London, UK

Co-Author: Eric Song, PhD, Immunome, Bothell, WA, USA

Co-Author: Kathryn Newhall, PhD, Immunome, Bothell, WA, USA

Co-Author: Jonathan Yovell, MD, Immunome, Bothell, WA, USA

Co-Author: Bernd Kasper, MD, PhD, Mannheim University Medical Center, Mannheim, Germany

2025 | Annual SPAGN Conference

Desmoid Tumors: Systemic Therapies Beyond Nirogacestat and Management Challenges in Brazil

Author: Fernando Campos, MD, MsC, Medical Oncologist Deputy Chair of the Sarcoma Reference Center, A.C.Camargo Cancer Center Sao Paulo, Brazil

2025 | ESMO Sarcoma and Rare Cancers Congress

Long-term Nirogacestat Treatment in Adult Patients with Desmoid Tumors: Updated Efficacy and Safety From the Phase 3 DeFi Trial

Author: Bernd Kasper, University of Heidelberg; Mannheim University Medical Center, Mannheim Cancer Center, Sarcoma Unit

Co-Author: Ravin Ratan, University of Texas, MD Anderson Cancer Center, Department of Sarcoma Medical Oncology, Division of Cancer Medicine

Co-Author: Thierry Alcindor, Dana Farber Cancer Institute, Harvard Medical School

Co-Author: Winette van der Graaf, Department of Medical Oncology, Netherlands Cancer Institute, Antoni van Leeuwenhoek; Department of Medical Oncology

Co-Author: Noah Federman, Departments of Pediatrics and Orthopedics, UCLA Jonsson Comprehensive Cancer Center, UCLA David Geffen School of Medicine

Co-Author: Nam Q. Bui, Division of Oncology, Department of Medicine, Stanford University

Co-Author: Gina D’Amato, Sylvester Comprehensive Cancer Center, University of Miami Health System

Co-Author: Richard F. Riedel, Duke Cancer Institute, Duke University Medical Center

Co-Author: Steven Attia, Department of Hematology and Oncology, Mayo Clinic

Co-Author: Sant Chawla, Sarcoma Oncology Center

Co-Author: Yucheng Chu, Sumptuous Data Sciences

Co-Author: Rachel Cohen, SpringWorks Therapeutics, Inc

Co-Author: Ana B. Oton, SpringWorks Therapeutics, Inc

Co-Author: Shengfan Zhou, SpringWorks Therapeutics, Inc

Co-Author: Brad Tumminello, SpringWorks Therapeutics, Inc

Co-Author: Mrinal Gounder, SpringWorks Therapeutics, Inc

2025 | ESMO Sarcoma and Rare Cancers Congress

The Association of Pain With Function for Adult Patients With Desmoid Tumor: Findings From the Desmoid Tumor Research Foundation Natural History Study

Author: Amanda Lucas, Desmoid Tumor Research Foundation, Philadelphia, PA, USA

Co-Author: Shengfan Zhou, SpringWorks Therapeutics, Inc., Stamford, CT, USA

Co-Author: Lynne Hernandez, Desmoid Tumor Research Foundation, Philadelphia, PA, USA

Co-Author: Yucheng Chu, Sumptuous Data Sciences, Monmouth Junction, NJ, USA

Co-Author: Timothy Bell, SpringWorks Therapeutics, Inc., Stamford, CT, USA

Co-Author: Ana B. Oton, SpringWorks Therapeutics, Inc., Stamford, CT, USA

Co-Author: Kelly Mercier, Desmoid Tumor Research Foundation, Philadelphia, PA, Duke University, Durham, NC, USA

2025 | ESMO Sarcoma and Rare Cancers Congress

Head, neck and shoulder desmoid-type fibromatosis: characteristics and outcome of these ultra-rare locations

Author: N Penel, Department of Medical Oncology, Centre Oscar Lambret, Lille; Univ. Lille, CHU Lille, ULR 2694 – Metrics : Evaluation des technologies de santé et des pratiques médicales, 59000 Lille, France

Co-Author: S Bonvalot, Department of Surgical Oncology, Institut Curie, Paris, and Université Paris Sciences et Lettres, Paris, France

Co-Author: J Elices-Diez, Clinical Research Department, Centre Oscar Lambret, Lille, France

Co-Author: A Italiano, Department of Medical Oncology, Institut Bergonié, Bordeaux, France

Co-Author: B Verret, Medical Oncology Department, Institut Paoli Calmettes, Marseille, France

Co-Author: JE Kurtz, Department of Medical Oncology, Strasbourg University Hospital, Strasbourg, France

Co-Author: P Dubray-Longeras, Department of Medical Oncology, Centre Jean Perrin, Clermont-Ferrand, France

Co-Author: C Guillemet, Medical Oncology Department, Centre Henri Becquerel, Rouen, France

Co-Author: F Duffaud, Medical Oncology Department, Public Assistance - Hospitals of Marseille, La Timone hospital, Marseille, France

Co-Author: F Bertucci, Medical Oncology Department, Institut Paoli Calmettes, Marseille, France

Co-Author: J Thery, Clinical Research Department, Centre Oscar Lambret, Lille, France

Co-Author: M Vanseymortier, Clinical Research Department, Centre Oscar Lambret, Lille, France

Co-Author: E Bompas, Medical Oncology Department, Centre René Gauduchau, Saint Herblain, France

Co-Author: N Firmin, Department of Medical Oncology, Institut du Cancer de Montpellier, Montpellier, France

Co-Author: P Boudou-Roquette, Department of Medical oncology, Hôpital Cochin-Saint-Vincent de Paul, Paris, France

Co-Author: J Wallet, Clinical Research Department, Centre Oscar Lambret, Lille, France

Co-Author: S Piperno-Neumann, Department of Medical Oncology, Institut Curie and INSERM U830, Institut Curie Research Center, Paris, France

Co-Author: T Valentin, Department of Medical oncology, Institut Claudius Regaud and Institut Universitaire de Cancerologie, Oncopole, Toulouse, France

Co-Author: JY Blay, Department of Medical oncology, Centre Léon Bérard and Université Claude Bernard, Lyon, France

Co-Author: MC Le Deley, Clinical Research Department, Centre Oscar Lambret, Lille, France

2024 | CTOS Annual Meeting

Nirogacestat Treatment in Adult Patients with Desmoid Tumors: Long-Term Efficacy and Safety From the Phase 3 DeFi Trial

Author: Ravin Ratan, MD, MEd, University of Texas, MD Anderson Cancer Center, Department of Sarcoma Medical Oncology, Division of Cancer Medicine, Houston, TX, USA

Co-Author: Bernd Kasper, MD, PhD, University of Heidelberg; Mannheim University Medical Center, Mannheim Cancer Center, Sarcoma Unit, Mannheim, Germany

Co-Author: Patrick Schöffski, Prof Dr, Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, KU Leuven, Leuven, Belgium

Co-Author: Winette van der Graaf, MD, PhD, Department of Medical Oncology, Netherlands Cancer Institute, Antoni van Leeuwenhoek, Amsterdam, Netherlands; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands

Co-Author: Noah Federman, MD, Departments of Pediatrics and Orthopedics, UCLA Jonsson Comprehensive Cancer Center, UCLA David Geffen School of Medicine, Los Angeles, CA, USA

Co-Author: Nam Quoc Bui, MD, Division of Oncology, Department of Medicine, Stanford University, Stanford, CA, USA

Co-Author: Allison Lim, PharmD, SpringWorks Therapeutics, Inc, Stamford, CT, USA

Co-Author: Shengfan Zhou, MS, SpringWorks Therapeutics, Inc, Stamford, CT, USA

Co-Author: Ana B. Oton, MD, SpringWorks Therapeutics, Inc, Stamford, CT, USA

Co-Author: Yucheng Chu, MS, Sumptuous Data Sciences, Monmouth Junction, NJ, USA

Co-Author: Brad Tumminello, PharmD, SpringWorks Therapeutics, Inc, Stamford, CT, USA

Co-Author: Mrinal Gounder, MD, Memorial Sloan Kettering Cancer Center; Weill Cornell Medical College, New York, NY, USA

2024 | CTOS Annual Meeting

Efficacy of Nirogacestat in Patients with Desmoid Tumors and Poor Prognostic Factors: Patient-Reported Outcomes, Progression-Free Survival, and Objective Response Rate in the Phase 3 DeFi Trial

Author: Bruno Vincenzi, MD, Prof, Policlinico Universitario Campus Bio-Medico, Rome, Italy

Co-Author: Nam Quoc Bui, MD, Stanford University, Stanford, CA, USA

Co-Author: Palma Dileo, MD, University College London Hospitals NHS Foundation Trust, London, United Kingdom

Co-Author: Noah Federman, MD, UCLA David Geffen School of Medicine, Los Angeles, CA, USA

Co-Author: Richard F. Riedel, MD, Duke Cancer Institute, Duke University, Durham, NC, USA

Co-Author: Brian A. Van Tine, MD, PhD, Washington University, Saint Louis, MO, USA

Co-Author: Shengfan Zhou, MS, SpringWorks Therapeutics, Inc, Stamford, CT, USA

Co-Author: Timothy Bell, MHA, SpringWorks Therapeutics, Inc, Stamford, CT, USA

Co-Author: Yucheng Chu, MS, Sumptuous Data Sciences, Monmouth Junction, NJ, USA

Co-Author: Allison Lim, PharmD, SpringWorks Therapeutics, Inc, Stamford, CT, USA

Co-Author: Ana B. Oton, MD, SpringWorks Therapeutics, Inc, Stamford, CT, USA

Co-Author: Bernd Kasper, MD, PhD, University of Heidelberg, Mannheim University Medical Center, Mannheim, Germany

2024 | CTOS Annual Meeting

The Effects of Ultrasound-Guided Histotripsy on Soft Tissue Sarcoma Desmoid Tumor Cohort Creation and Characteristics in the Veterans Affairs (VA) National Database

Author: Sarah E. Lindsay, MD, OHSU Department of Orthopaedics & Rehabilitation

Co-Author: Cecelia Madison, MS, Portland VA Medical Center Operative Care Division

Co-Author: Dipam Doshi, PharmD, SpringWorks Therapeutics Inc.

Co-Author: Susan Scott, MSN, SpringWorks Therapeutics Inc.

Co-Author: Tim Bell, MHA, SpringWorks Therapeutics Inc.

Co-Author: Sunny Cho, PharmD, SpringWorks Therapeutics Inc.

Co-Author: Duncan Ramsey MD, MS, OHSU Department of Orthopaedics & Rehabilitation

Co-Author: Yee-Cheen Doung, MD, OHSU Department of Orthopaedics & Rehabilitation

Co-Author: Kenneth R. Gundle, MD, OHSU Department of Orthopaedics & Rehabilitation, Portland VA Medical Center Operative Care Division

2024 | CTOS Annual Meeting

The Effects of Ultrasound-Guided Histotripsy on Soft Tissue Sarcoma

Author: Emma Kenna, Cancer Biology, University of Michigan Medical School, Ann Arbor, MI

Co-Author: Lexi-Ann F. Golden, Cancer Biology; University of Michigan Medical School, Ann Arbor, MI

Co-Author: James Messina, Department of Biomedical Engineering; University of Michigan, Ann Arbor, MI

Co-Author: Ryan Hubbard, Department of Biomedical Engineering; University of Michigan, Ann Arbor, MI

Co-Author: Kyle Perry, MD, Department of Pathology; University of Michigan Medicine, Ann Arbor, MI

Co-Author: Amanda Shafer, Department of Surgery; University of Michigan Medicine, Ann Arbor, MI

Co-Author: Ashley Cornett, Department of Biomedical Engineering; University of Michigan, Ann Arbor, MI

Co-Author: Brynn Kackzkofsky, Department of Surgery; University of Michigan Medicine, Ann Arbor, MI

Co-Author: Jodi Wilkowski, Department of Surgery; University of Michigan Medicine, Ann Arbor, MI

Co-Author: Steven Soliman, MD, Department of Radiology, University of Michigan Medicine, Ann Arbor, MI

Co-Author: Gunjan Malhotra, MD, Department of Radiology, University of Michigan Medicine, Ann Arbor, MI

Co-Author: Geoffrey Siegel, MD, Department of Orthopaedic Surgery, University of Michigan Medicine, Ann Arbor, MI

Co-Author: Jonathan Sukovich, Department of Biomedical Engineering; University of Michigan, Ann Arbor, MI

Co-Author: Timothy Hall, Department of Biomedical Engineering; University of Michigan, Ann Arbor, MI

Co-Author: Zhen Xu, Department of Biomedical Engineering; University of Michigan, Ann Arbor, MI

Co-Author: Christina V. Angeles, MD, Cancer Biology; University of Michigan Medical School, Department of Surgery; University of Michigan Medicine, Ann Arbor, MI

2024 | CTOS Annual Meeting

Pegylated liposomal doxorubicin in symptomatic desmoid tumor

Author: Kjetil Boye, Department of Oncology, Oslo University Hospital, Oslo, Norway

Co-Author: Annette Torød Skeie, Department of Radiology, Oslo University Hospital, Oslo, Norway

Co-Author: Marthe Rosvoll Kobbeltvedt, Department of Oncology, Oslo University Hospital, Oslo, Norway

Co-Author: Lisbeth Hårklau, Department of Gastroenterological Surgery, Oslo University Hospital, Oslo, Norway

Co-Author: Anthony Burton Mariathasan, Department of Gastroenterological Surgery, Oslo University Hospital, Oslo, Norway

Co-Author: Gia Hoang Nam Nguyen, Department of Orthopedic Surgery, Oslo University Hospital, Oslo, Norway

Co-Author: Ingvild Lobmaie, Department of Pathology, Oslo University Hospital, Oslo, Norway

Co-Author: Tord Hompland, Department of Radiation Biology, Oslo University Hospital, Oslo, Norway

Co-Author: Ivar Hompland, Department of Oncology, Oslo University Hospital, Oslo, Norway

2024 | CTOS Annual Meeting

TRANSCRIPTOMIC ANALYSIS OF DESMOID TUMOR RESPONSE TO NIROGACESTAT: NOVEL MECHANISMS OF RESISTANCE?

Author: Alvarez J, Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University

Co-Author: Basu Mallick A, Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University

Co-Author: Blomain ES, Department of Radiation Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University

2024 | CTOS Annual Meeting

Targeting the O-GlcNAcase Transferase in Leiomyosarcoma and Desmoid-type Fibromatosis

Author: Richard Miallot, Cancer Research Program, The Research Institute of the McGill University Health Centre, Department of Surgery, McGill University, Montreal, QC, Canada

Co-Author: Sandip Das, Georgia Institute of Technology, Atlanta, GA, USA

Co-Author: Raphael Pollock, The Ohio State University College of Medicine, Columbus, OH, USA

Co-Author: Jonathan Fletcher, Pathology Department, Brigham And Women's Hospital, Boston, MA, USA

Co-Author: Joanna Przybyl, Cancer Research Program, The Research Institute of the McGill University Health Centre, Department of Surgery, McGill University, Montreal, QC, Canada

2024 | CTOS Annual Meeting

MULTI-OMIC AND MULTI-REGION PROFILING OF DESMOID TUMORS REVEALS INTRA- AND INTER-TUMOR HETEROGENEITY

Author: Chelsea De Bellis, Department of Surgery, McGill University, Montreal, QC, Canada

Co-Author: Sujay Vennam, Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA

Co-Author: Christopher Eeles, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada

Co-Author: Justin Cates, PathGroup Laboratories, Nashville, TN, USA

Co-Author: Thomas Stricker, One Oncology, Nashville TN, USA

Co-Author: Kristen Ganjoo, Department of Medicine, Division of Medical Oncology, Stanford University, Stanford, CA, USA

Co-Author: Benjamin Haibe-Kains, Princess Margaret Cancer Centre, University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, Canada & Cancer Research Program, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada

Co-Author: Joanna Przybyl, Department of Surgery, McGill University, Cancer Research Program, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada

2024 | CTOS Annual Meeting

Descriptive Evaluation of Patients With Desmoid Tumor and Co-Occurring Somatic Mutations of CTNNB1 and APC in the Phase 3 DeFi Trial

Author: Bernd Kasper, MD, PhD, Sarcoma Unit, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany

Co-Author: Noah Federman, MD, Departments of Pediatrics and Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA

Co-Author: Peter Reichardt, MD, PhD, Helios Hospital Berlin-Buch, Berlin, Germany

Co-Author: Richard F. Riedel, MD, Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA

Co-Author: Allison Lim, PharmD, SpringWorks Therapeutics, Inc., Stamford, CT, USA

Co-Author: Vincent Amoruccio, PhD, SpringWorks Therapeutics, Inc., Stamford, CT, USA

Co-Author: Brian A. Van Tine, MD, PhD, Siteman Cancer Center, Washington University, School of Medicine, St. Louis, MO, USA

2024 | CTOS Annual Meeting

Utilization of Mental Health and Supportive Care Resources Among Patients with Desmoid Tumors

Author: Victoria Wytiaz, MD, University of Michigan, Department of Oncology

Co-Author: Patrick Gaulier, MSW, University of Michigan Department of Social Work

Co-Author: Scott Schuetze, MD, University of Michigan, Department of Oncology

Co-Author: Christina Angeles, MD, University of Michigan, Department of Surgery

Co-Author: Amanda Fox, PA, University of Michigan, Department of Oncology

Co-Author: Laurie Zyczynski, PA, University of Michigan, Department of Oncology

Co-Author: Rashmi Chugh, MD, University of Michigan, Department of Oncology

2024 | ESMO Sarcoma and Rare Cancers Congress

45P “The Patient Voices: Revealing the Challenges Faced by Persons with Desmoid Tumors in a Middle-Income Country”

Author: Carolina Maria de Menezes Chaves, Desmoid Tumor Brazilian Association - Desmoide Brasil, São Paulo, SP, Brazil

Co-Author: Livia Prudente Barbieri MD, Desmoid Tumor Brazilian Association - Desmoide Brasil, São Paulo, SP, Brazil

Co-Author: Bruna Bianca Lopes David MD, epartment of Medicine, Division of Oncology, Brazilian National Cancer Institute, Rio De Janeiro, RJ, Brazil: Oncoclinicas Group. Rio de Janeiro. RJ, Brasil

Co-Author: Celso Abdon Lopes de Mello MD, PhD, Sarcoma Reference Center, A.C. Camargo Cancer Center, São Paulo, SP. Brazil

Co-Author: Fernando Campos MD, Sarcoma Reference Center, A.C. Camargo Cancer Center, São Paulo, SP. Brazil

Co-Author: Georgia Garofalo Mounssef, Desmoid Tumor Brazilian Association - Desmoide Brasil, São Paulo, SP, Brazil

Co-Author: Philippos Apolinario Costa MD, Department of Medicine, Division of Oncology, Yale School of Medicine

2024 | ESMO Sarcoma and Rare Cancers Congress

Impact of Nirogacestat on Patient-Reported Outcomes in Adults with Desmoid Tumor with a Best Overall Response of Stable Disease: Post Hoc Analysis fromThe DeFi Study

Author: Silvia Stacchiotti, et al (Complete author information is listed on presentation.)

2024 | ESMO Sarcoma and Rare Cancers Congress

Treatment Landscape for Desmoid Tumors: Desmoid Tumor Research Foundation Natural History Study

Author: Kelly Mercier, PhD - Desmoid Tumor Research Foundation, Duke University

Co-Author: Shengfan Zhou, MS - SpringWorks Therapeutics, Inc.

Co-Author: Ana Oton, MD - SpringWorks Therapeutics, Inc.

Co-Author: Timothy Bell, MHA - SpringWorks Therapeutics, Inc.

Co-Author: Lynne Hernandez, BA - Desmoid Tumor Research Foundation

Presenter & Co-Author: Amanda Lucas, BS - Desmoid Tumor Research Foundation

2024 | ESMO Sarcoma and Rare Cancers Congress

Impact of Desmoid Tumors on Patients’ Quality of Life: Desmoid Tumor Research Foundation Natural History Study

Author: Kelly Mercier, PhD - Desmoid Tumor Research Foundation, Duke University

Co-Author: Shengfan Zhou, MS - SpringWorks Therapeutics, Inc.

Co-Author: Brad Tumminello, PharmD - SpringWorks Therapeutics, Inc.

Co-Author: Timothy Bell, MHA - SpringWorks Therapeutics, Inc.

Co-Author: Lynne Hernandez, BA - Desmoid Tumor Research Foundation

Presenter & Co-Author: Amanda Lucas, BS - Desmoid Tumor Research Foundation

2023 | CTOS Annual Meeting

INVESTIGATING THE ROLE OF LIQUID BIOPSY IN DESMOID FIBROMATOSIS DURING ACTIVE SURVEILLANCE

Author: Laura Bergamaschi, MSc (she/her/hers) – Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Co-Author: Marta Zorza, n/a – Fondazione IRCCS Istituto Nazionale dei Tumori

Co-Author: Francesca Rini, n/a – Fondazione IRCCS Istituto Nazionale dei Tumori

Co-Author: Federica Perrone – Fondazione IRCCS Istituto Nazionale dei Tumori

Co-Author: licia Rivoltini, MD, PhD – Fondazione IRCCS Istituto Nazionale dei Tumori

Co-Author: Alessandro Gronchi, MD, FSSO (he/him/his) – Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Co-Author: Sandro Pasquali, MD, PhD – Fondazione IRCCS Istituto Nazionale dei Tumori

Co-Author: Viviana Vallacchi, PhD – Fondazione IRCCS Istituto Nazionale dei Tumori

Presenter: Chiara Colombo, MD – Department of Surgery, Sarcoma Service, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

2023 | CTOS Annual Meeting

PDGFRβ AND C-ABL ACTIVATION ASSOCIATE WITH OUTCOME AND RESPONSE TO SORAFENIB IN DESMOID PATIENTS TREATED ON THE PHASE III ALLIANCE A091105 TRIAL

Co-Author: Jia Hu, PhD – Memorial Sloan Kettering Cancer Center

Co-Author: Meera Hameed, MD – Memorial Sloan Kettering Cancer Center

Co-Author: Narasimhan Agaram, MBBS – Memorial Sloan Kettering Cancer Center

Co-Author: Karissa Whiting, MS – Memorial Sloan Kettering Cancer Center

Co-Author: Li-Xuan Qin, PhD (she/her/hers) – Memorial Sloan Kettering Cancer Center

Co-Author: Anthony M. Villano, MD (he/him/his) – Fox Chase Cancer Center

Co-Author: Rachael O’Connor, BS – Memorial Sloan Kettering Cancer Center

Co-Author: Yuliy Rozenberg, PhD – Memorial Sloan Kettering Cancer Center

Co-Author: Sonia Cohen, MD – Memorial Sloan Kettering Cancer Center

Co-Author: Katherine Prendergast, MD – Memorial Sloan Kettering Cancer Center

Co-Author: Richard White, MD – Atrium Health

Co-Author: Mitchell Posner, MD – University of Chicago

Co-Author: Nicholas Socci, PhD – Memorial Sloan Kettering Cancer Center

Co-Author: Samuel Singer, MD, FACS – Memorial Sloan Kettering Cancer Center

Co-Author: Mrinal Gounder, MD – Memorial Sloan Kettering Cancer Center

Author: Aimee M. Crago, MD, PhD, FACS (she/her/hers) – Memorial Sloan Kettering Cancer Center

2023 | CTOS Annual Meeting

(P14) PERCUTANEOUS CRYOABLATION OF PROGRESSING EXTRA-ABDOMINAL DESMOID TUMOURS

Andrea Vanzulli, MD – Università degli Studi di Milano

Lucilla V. Sciacqua, MD – Università degli Studi di Milano

Tommaso Cascella, MD – Fondazione IRCCS Istituto Nazionale dei Tumori

Carlo Spreafico, M.D. – Fondazione IRCCS Istituto Nazionale dei Tumori

Chiara Colombo, MD – Department of Surgery, Sarcoma Service, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Elena Palassini, N/A, MD – Department of Medical Oncology 2, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

Alessandro Gronchi, MD, FSSO – Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Carlo Morosi, MD – Department of Radiology, Fondazione IRCSS Istituto Nazionale Tumori, Milan, Italy

2023 | CTOS Annual Meeting

(P219) ELECTIVE DISCONTINUATION OF SORAFENIB TREATMENT IN DESMOID TUMORS: A RETROSPECTIVE ANALYSIS WITH IMPLICATIONS FOR CLINICAL PRACTICE

Nikita Shah, M.D. – Northwestern Memorial Hospital

Ayra Faruqi, MD – Northwestern Medicine

Borislav Alexiev, M.D. – Northwestern Memorial Hospital

John Hayes, M.D. – Northwestern Memorial Hospital

Susan Abbinanti, M.D. – Northwestern Memorial Hospital

Fahad Faruqi, M.D., M.P.H – Northwestern Medicine

Akhil Chawla, MD – Northwestern Memorial Hospital

Terrance Peabody, M.D. – Northwestern Memorial Hospital

Samer Attar, M.D. – Northwestern Memorial Hospital

Jeff Wayne, M.D. – Northwestern Memorial Hospital

Seth Pollack, MD – Robert H. Lurie Comprehensive Cancer Center of Northwestern University

Pedro Viveiros, MD – Northwestern University

Vinai Gondi, M.D. – Northwestern Memorial Hospital

2023 | CTOS Annual Meeting

(P221) EARLY RESULTS IN NOVEL USE OF CONTRAST-ENHANCED SUSCEPTIBILITY-WEIGHTED IMAGING IN THE ASSESSMENT OF RESPONSE AND PROGRESSION IN DESMOID FIBROMATOSIS: PILOT STUDY IN A SPECIALIZED CANCER INSTITUTION

Raul F. Valenzuela, M.D – MD Anderson Cancer Center

Behrang Amini, M.D, PhD – MD Anderson Cancer Center

Elvis Duran Sierra, PhD – MD Anderson Cancer Center

Mathew Antony, M.D – MD Anderson Cancer center

Colleen Costelloe, M.D – MD Anderson Cancer center

John E. Madewell, M.D – MD Anderson Cancer Center

William A. Murphy, Jr., M.D – M.D Anderson Cancer center

2023 | CTOS Annual Meeting

(P158) SORAFENIB OR ANTHRACYCLINE-BASED CHEMOTHERAPY IN ADULT PATIENTS WITH PROGRESSIVE DESMOID TUMORS

Philippos A. Costa, MD – Yale University

Arshia Arora, MD – University of Miami

Nipat Chuleerarux, MD – University of Miami

Leticia Campoverde, MD – University of Miami

Yanelys Fernandez, MD – University of Miami

Baylee Bakkila, BS, BA – Yale University

Heng Tan, MD – University of Miami

Priscila Barreto coelho, MD – University of Miami

Andrea P. Espejo-Freire, MD – University of Minnesota

Gina Z. D’Amato, MD – Sylvester Comprehensive Cancer Center

Emily Jonczak, MD – Sylvester Comprehensive Cancer Center / University of Miami Hospital and Clinics

Ty Subhawong, MD – University of Miami

Hari Deshpande, MD – Yale University

Kelly Olino, MD – Yale University

Jonathan Trent, MD – University of Miami

2023 | CTOS Annual Meeting

(P342) THE EVALUATION AND OUTCOMES OF MESENTERIC AND INTRA-ABDOMINAL DESMOIDS: A TARPSWG STUDY

Tristan Wild, BMSc – University of Ottawa

Kerianne Boulva, MD – The Centre hospitalier de l’Université de Montréal (CHUM)

Francesco Barretta, PhD – Fondazione IRCCS IStituto Nazionale dei Tumori, Milan, Italy

Kenneth Cardona, MD – Department of Surgery, Winship Cancer Institute, Emory University

Elena Palassini, N/A, MD – Department of Medical Oncology 2, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

Peter Hohenberger, N/A, n/a – Sarcoma Unit, Department of Surgery and Mannheim Cancer Center, University Medical Center Mannheim, University of Heidelberg, Mannheim,Germany

Shintaro Iwata, MD – National Cancer Center Hospital

Rebecca Gladdy, MD, PhD – Mount Sinai Hospital, Sinai Health System, and Princess Margaret Cancer Centre Toronto, ON, Canada Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada University of Toronto, Toronto, ON

Christina V. Angeles, MD – Department of Surgery, Rogel Cancer Center, University of Michigan

Neha Goel, MD – Miami University

Pawel Sobczuk, MD PhD – Maria Sklodowska-Curie National Research Institute of Oncology

Samuel Ford, MD, PhD – Department of Surgery, University Hospitals Birmingham

Greg Sigler, MD – University of Ottawa

Dan Blazer, III, MD – Duke University

Winan J. van Houdt, MD, PhD, MS – Netherlands Cancer Institute/ Antoni van Leeuwenhoek

Stephanie H. Greco, MD – Fox Chase Cancer Center

Fabian Johnston, MD, MHS – Johns Hopkins

Vittorio Lorenzo Quagliuolo, MD – IRCCS Humanitas Research Hospital

Samuel Aguiar, MD – A.C. Camargo

Elisabetta Pennacchioli, MD – Division of Melanoma, Sarcoma, and Rare Tumor Surgery, European Institute of Oncology

Dagmar Adámková Krákorová, MD, PhD – Masaryk Memorial Cancer Institute Brno, Czech Republic

Sameer Rastogi, DM – Department of medical oncology, Dr BRAIRCH, All India Institute of Medical Sciences

Chandrajit P. Raut, MD, MSc – Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston

Hayden Snow, MD – Peter MacCallum Cancer Centre

Palma Dileo, MD – University College Hospital

Guy Lahat, MD – Tel Aviv Sourasky Medical Center

Jos A. van der Hage, MD PhD – Leiden University Medical Center

Attila Kollar, MD – Department of Medical Oncology, University Hospital Bern, Inselspital, Switzerland

Alessandro Gronchi, MD, FSSO – Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Carolyn Nessim, MD – Department of Surgery, University of Ottawa

2023 | CTOS Annual Meeting

(P554) FIVE-YEAR OUTCOMES OF A NATIONWIDE PROSPECTIVE CLINICAL TRIAL ON ACTIVE SURVEILLENCE IN PATIENTS WITH NON-INTRAABDOMINAL DESMOID-TYPE FIBROMATOSIS

Stefanie N. Hakkesteegt, MD – Erasmus Medical Center

Anne-Rose W. Schut, MD – Erasmus Medical Center

Milea J.M. Timbergen, MD, PhD – Erasmus Medical Center

Danique L.M. Van Broekhoven, MD, PhD – Erasmus Medical Center

Thijs van Dalen, MD, PhD – Erasmus Medical Center

Winan J. van Houdt, MD, PhD, MS – Netherlands Cancer Institute/ Antoni van Leeuwenhoek

Han Bonenkamp, Dr. – Radboud university medical center

Stefan Sleijfer, MD, PhD – Erasmus Medical Center

Dirk J. Grünhagen, MD, PhD – Erasmus Medical Center

Cornelis Verhoef, MD, PhD – Erasmus Medical Center

2023 | CTOS Annual Meeting

(P549) DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL OF AL102 FOR TREATMENT OF PROGRESSING DESMOID TUMORS: THE RINGSIDE PHASE 3 STUDY DESIGN

Piotr Rutkowski, MD, PhD – Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, Department of Soft Tissue/Bone Sarcoma and Melanoma

Mrinal Gounder, MD – Memorial Sloan Kettering Cancer Center

Robin L. Jones, BSc, MB BS, MRCP, MD – Sarcoma Unit, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research

Jonathan Y. Yovell, MD – Ayala Pharmaceuticals

Gary Gordon, MD, PhD – Ayala Pharmaceuticals

Andres A. Gutierrez, MD, PhD – Ayala Pharmaceuticals

Bernd Kasper, MD, PhD – University of Heidelberg, Mannheim University Medical Center

2023 | CTOS Annual Meeting

(P395) TARGETING CD44-MEDIATED IRON ENDOCYTOSIS IN DESMOID FIBROMATOSIS

Stéphanie Solier, PharmD-PhD – Institut Curie

Olivier Delattre, PhD – Institut Curie

Pierre Gestraud, PhD – Institut Curie

Chloé Quignot, PhD – Institut Curie

Sylvie Bonvalot, MD, PhD – Institut Curie

Dimitri Tzanis, MD, PhD – Institut Curie

Sophie El Zein, MD – Institut Curie

Laetitia Lesage, n/a – Institut Curie

Joshua J Waterfall, PhD – Institut Curie

Raphaël Rodriguez, PhD – Institut Curie

Sarah Watson, MD, PhD – Institut Curie

2023 | CTOS Annual Meeting

(P333) SYSTEMIC TREATMENT IN INTRA-ABDOMINAL DESMOID-TYPE FIBROMATOSIS: A SINGLE INSTITUTION RETROSPECTIVE CASE SERIES ANALYSIS

Ilaria Pellegrini, MD – Department of Medical Oncology 2, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Francesca Ligorio, MD – Department of Medical Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Chiara Colombo, MD – Department of Surgery, Sarcoma Service, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Marco Fiore, MD, FEBS, FACS – Department of Surgery, Sarcoma Service, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Salvatore Provenzano, MD – Mesenchymal and rare cancer Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Carlo Morosi, MD – Department of Radiology, Fondazione IRCSS Istituto Nazionale Tumori, Milan, Italy

Ciriaco Buonomenna, MD – Department of Radiology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Marco Vitellaro, MD – Department of Surgery, Hereditary Digestive Tract Tumors Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Paola Collini, MD – Department of Advanced Diagnostics , Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Alessandro Gronchi, MD, FSSO – Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Paolo Giovanni G. Casali, MD – Department of Medical Oncology 2, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

Elena Palassini, N/A, MD – Department of Medical Oncology 2, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

2023 | CTOS Annual Meeting

(P241) ASSOCIATION OF ADC VALUES WITH DESMOID TUMOR SHRINKAGE DURING ACTIVE OBSERVATION

Masato Sugawara, MD, PhD – Yamagata University Faculty of Medicine, Department of Orthopaedic Surgery

Daiichiro Takahara, M.D. – Yamagata University Faculty of Medicine, Department of Orthopaedic Surgery

Chiomi Shirai, M.D. – Yamagata University Faculty of Medicine, Department of Orthopaedic Surgery

Michiaki Takagi, M.D., Ph.D. – Yamagata University Faculty of Medicine, Department of Orthopaedic Surge

2023 | CTOS Annual Meeting

(P12) MULTIFOCAL AND DISSEMINATED SPORADIC DESMOID TUMOUR OF THE EXTREMITIES: A SPECIAL CHALLENGE

Franka Menge – Sarcoma Unit, Department of Surgery and Mannheim Cancer Center, University Medical Center Mannheim, University of Heidelberg, Mannheim,Germany

Peter Hohenberger, N/A, n/a – Sarcoma Unit, Department of Surgery and Mannheim Cancer Center, University Medical Center Mannheim, University of Heidelberg, Mannheim,Germany

Bernd Kasper, MD, PhD – University of Heidelberg, Mannheim University Medical Center

Eva Wardelmann, MD – Institute of Pathology,.University Hospital Muenster

Florian Haller, N/A, n/a – Department of Pathology Friedrich- Alexander- Universität Erlangen-Nürnberg, Erlangen

Jens Jakob, MD – University Medical Center Mannheim, University of Heidelberg

2023 | CTOS Annual Meeting

IMPACT OF NIROGACESTAT ON FUNCTIONAL STATUS IN PATIENTS WITH DESMOID TUMORS: RESULTS FROM THE PHASE 3 DEFI STUDY

Bernd Kasper, MD, PhD – University of Heidelberg, Mannheim University Medical Center

Mrinal Gounder, MD – Memorial Sloan Kettering Cancer Center

Ravin Ratan, MD – The University of Texas MD Anderson Cancer Center

Timothy Bell, MHA – SpringWorks Therapeutics, Inc.

Cristina Ivanescu, PhD – IQVIA

James Marcus, PhD – IQVIA

Allison Lim, PharmD – SpringWorks Therapeutics Inc

Sandra Goble, MS – SpringWorks Therapeutics Inc

Sunny Cho, PharmD – SpringWorks Therapeutics Inc

Thierry Alcindor, MS, MSc – McGill University

Winette van der Graaf, Prof. Dr. – Netherlands Cancer Institute/ Antoni van Leeuwenhoek

Patrick Schöffski, MD, MPH – Department of General Medical Oncology, University Hospitals Leuven, and Laboratory of Experimental Oncology, KU Leuven, Leuven Cancer Institute, Leuven, Belgium

Breelyn A. Wilky, MD – University of Colorado Cancer Center charlotte Benson, MBChB, FRCP – The Royal Marsden Hospital

Nam Bui, MD – Stanford University

Rashmi Chugh, MD – University of Michigan Rogel Cancer Center

Shivaani Kummar, MD, FACP – Oregon Health & Science University

Richard F. Riedel, MD – Duke Cancer Institute

First Place Winner in the CTOS poster category “Improving Sarcoma Care Globally”

2023 | CTOS Annual Meeting

(P146) CHARACTERIZING THE PATIENT JOURNEY TO A DIAGNOSIS OF DESMOID TUMOR: DESMOID TUMOR RESEARCH FOUNDATION NATURAL HISTORY STUDY

Shengfan Zhou, MS – SpringWorks Therapeutics Inc.

Amanda Lucas, BS – Desmoid Tumor Research Foundation

Lynne Hernandez, BA – Desmoid Tumor Research Foundation

Timothy Bell, MHA – SpringWorks Therapeutics, Inc.

Mitchell Allen – SpringWorks Therapeutics Inc.

Sandra Goble, MS – SpringWorks Therapeutics Inc.

Kelly Mercier, PhD – Desmoid Tumor Research Foundation