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The Desmoid Tumor Research Foundation

DTRF Announces The First Publicly Available Desmoid Tumor Immortal Cell Line

Cell Lines

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We are thrilled to announce that through our research at Broad Institute of MIT and Harvard and partnership with Pattern.org, the first publicly available desmoid tumor immortal cell line has been generated and is now available to researchers worldwide.

Cell lines are critical for researchers to learn more about the disease and in testing new therapeutic options. The availability of this cell line is an initial, but very significant milestone as we work to provide verified and standardized resources to our research community.
We thank all of our patients who have consented to donate tissue through Pattern.org as you are instrumental in helping expedite the development of improved therapies and ultimately find a cure for desmoid tumors. If you have an upcoming surgery and would like to donate, please visit our Donate Your Tissue page for more information.

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We are excited to announce that two, stable, long-term desmoid tumor cell lines will be available for researchers to access soon.

With the support of the DTRF, Mushriq Al-Jazrawe, PhD, a postdoctoral fellow at Boehm Lab, has successfully created two stable cell lines that replicate the features of desmoid tumors. The stable cell lines can survive for long periods of time in the lab, making it easier to study desmoid tumors and perform large-scale experiments. One of these cell lines harbors a T41A mutation in the CTNNB1 gene, while the other has an S45F mutation. The cell lines will be available soon through American Type Culture Collection (ATCC).

ATCC is a private, nonprofit, global biological resource center and standards organization that provides scientists with the biomaterials and resources they need to conduct critical life science research. ATCC is one of the world’s largest suppliers of cell lines to labs around the world.

This project is only possible with our community’s support. If you would like to help champion desmoid tumor research initiatives like these, please consider making a donation.


Learn more about Desmoid Tumor Cell Lines