“Do factors mediate desmoid tumor invasiveness and drug sensitivity?” Year 2 of 2

Conclusions: 1. MMP1 (matrix metallopeptidase) expression predominant in highly invasive FAP-related DT while MMP3 more representative of less invasive sporadic DT. (two manuscripts in progress) 2.FAP desmoids are more likely resistant to chemo than sporadic DT. Dr. David Joyner will continue to contribute to the DTRF collaborative effort that was initiated during the May 2008 Symposium.