Pathogenesis of desmoid-type fibromatosis has been investigated and the CTNNB1 mutation has been identified as a genetic factor for the development of this disease, particularly of sporadic ones. Treatment modality including surgical treatment with tumor-free margin, various conservative drug therapies, radiotherapy, and wait & see policy has been applied to patients of this disease. Although several recent studies demonstrated that CTNNB1 mutation status is significantly associated with the clinical outcomes of the treatment, particularly of surgery, other studies did not. Traditionally, desmoid-type fibromatosis is considered to arise in the area of trauma, such as surgical trauma of Caesarean operation. Many studies revealed that clinical outcomes and/or disease course depend on the site of onset of this disease. Patients with disease in lower extremity were reported to have poorer outcomes. Taking these together, disease behavior and efficacy of various treatment could be affected microenvironmentally. We hypothesize that desmoid cells and tumors are affected by the mechanical forces, and planned to investigate the effects of mechanical forces on the cell proliferation and motility, biochemical and molecular biological responses.
LAY VERSION OF ABSTRACT- “Effects of mechanical forces on the cell and tumor behavior of desmoid-type fibromatosis.”
