The Desmoid Tumor Research Foundation

August 2025

Congenital Desmoid Tumor of the Larynx: A Therapeutic Challenge

Author Information

Saúl Astray Gómez 1, Santiago Almanzo 1 2, Adrián Hernández Moya 3, Agustín Alamar Velázquez 1 2, Miguel Armengot Carceller 1 2

1Department of Otorhinolaryngology, Hospital Universitari i Politecnic La Fe, Valencia, Spain. 2University of Valencia, Valencia, Spain. 3Department of Anesthesiology and Intensive Care, Hospital Universitari i Politecnic La Fe, Valencia, Spain.

Publication

Indian J Otolaryngol Head Neck Surg

Summary

Desmoid tumors affecting vital structures can be life-threatening despite their non-malignant behavior. The lack of standardized treatment poses a therapeutic challenge, particularly regarding the sequelae in pediatric patients. A one-month-old male patient presented with respiratory distress and stridor. Endoscopic exploration and computed tomography revealed a laryngeal tumor, which was confirmed as a desmoid tumor via biopsy. Systemic chemotherapy in combination with imatinib was initiated, leading to stabilization of the tumor size. A surgical approach for desmoid tumors may be unsuitable for pediatric patients due to excessive morbidity. In such cases, targeted therapies like tyrosine kinase inhibitors can effectively control the disease.

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