The Desmoid Tumor Research Foundation

May 2021

Cryo-surgery for symptomatic extra-abdominal desmoids. A proof of concept study

Author Information

Efrima B (1, 2), Ovadia J (2), Drukman I (2, 3), Khoury A (1), Rath E (1, 2), Dadia S (1, 2), Gortzak Y (2, 4), Albagli A (1, 2), Sternheim A (2 ,4), Segal O (2, 4).

(1) Div of Orthopaedic Surgery, Tel Aviv Medical Center, Tel Aviv, Israel., (2) Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, (3) Div of Radiology, Tel Aviv Medical Center, Tel Aviv, Israel, (4) National Dept of Orthopaedic Oncology, Tel Aviv Medical Center, Tel Aviv, Israel.

Publication

J Surg Oncol

Summary

Current treatment modalities show high levels of recurrence and comorbidities for extra-abdominal desmoids. Cryo-surgery as an alternative was subsequently investigated. In this retrospective, single center study 11 patients showing symptomatic tumors were treated with individualized cryo-surgery. Treatment protocol included preoperative planning using computer rendered 3D models, intraoperative navigation and execution using cone beam guidance, and postoperative magnetic resonance imaging image analysis using a gaussian mixture model software. Subjective outcomes were reported using Short Form Health Survey (SF-36) questionnaires. Conclusion: Cryo-surgery using the three-phase protocol as described may improve the overall outcome of future ablation procedures.

View Abstract