Yang S(1), Wang X(2), Jiang H(1), Wang Y(3), Li Z(4)(5), Lu H(1)
(1)Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, China.(2)Department of Nuclear medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.(3)Department of Thoracic surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.(4)BGI-Qingdao Institute, Qingdao SINO-GERMAN Ecopark, Qingdao, China.(5)BGI-Shenzhen, Shenzhen, China.
Publication
Cancer Biol Ther
Summary
In the case report, a 39-year-old man presented with progressive chest wall pain. Computed tomography (CT) showed an approximately 46 _ 13mm soft-tissue mass between the inside of the fifth and sixth rib on the right side. The entire mass was excised and an AF was confirmed based on histopathology. Four months after surgery, magnetic resonance imaging(MRI) showed a soft-tissue mass in surgical areas and biopsy confirmed local recurrence. Therefore, Tomotherapy was administered. However, two months later, an (18)F-fluorodeoxyglucose (FDG) Positron Emission Tomography combined with CT (PET-CT) revealed the presence of an FDG-avid mass in the area of local recurrence. Genetic testing reported the presence of a p.T41A mutations on the CTNNB1 gene, which predicted that he is sensitive to the COX-2 inhibitor celecoxib. The tumor regressed rapidly after the application of celecoxib. Within the 20-month follow-up period, the patient showed remarkable regression without any signs and symptoms. Our case report provides further evidence for the efficacy of celecoxib in AF with CTNNB1 gene mutations. To our knowledge, this is the first report of AF treated with celecoxib under the guidance of the genetic testing. However, further studies are required.
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