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The Desmoid Tumor Research Foundation

November 2017

The Characteristics and Treatment Outcomes for Desmoid Tumors Associated with Familial Adenomatous Polyposis (in Japanese)

Author Information

Amano K(1), Chika N, Ito T, Yamamoto A, Hatano S, Ishiguro T, Fukuchi M, Kumagai Y, Ishibashi K, Mochiki E, Iwama T, Eguchi H, Okazaki K, Inokuma S, Ishida H

(1)Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University

Publication

Gan To Kagaku Ryoho

Summary

The characteristics of desmoid tumors(DTs) associated with familial adenomatous polyposis(FAP) and relationships between the development of DTs and the sites of APC germline mutation have not closely been examined in Japan. This retrospective study was performed to address these issues by examining patients with FAP who underwent proctocolectomy between 1981 and 2015. The frequency of DTs development and genotype-phenotype relationship of FAP patients seems to concur with those reported from Western countries. Since the DOX plus DTIC therapy for severe DTs is valid but toxicity is high, the development of less toxic regimens are warranted.

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