The Desmoid Tumor Research Foundation

January 1970

Undervaluation of Radiotherapy for Gross Desmoid Tumors: The Need for Absolute Volume Assessment

Author Information

Kim YJ(1), Song SY(1), Kim W(2), Lee J(2), Ahn JH(3), Kim JE(3), Chung HW(4), Jeong SY(5), Choi EK(1).

(1)Dept of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. (2)Dept of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. (3)Dept of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.(4)Dept of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. (5)Asan Cancer Institute, Seoul, Republic of Korea.

Publication

In Vivo

Summary

To compare absolute volume (AV) assessment according to Response Evaluation Criteria in Solid Tumors (RECIST) for the response evaluation of desmoid tumors (DTs) treated with radiotherapy. Eighteen patients with DTs ?3 cm in size were included. The median follow-up duration was 78.0 months. Five patients achieved a complete response according to RECIST, seven reached a partial response (PR), and one eventually exhibited progression. The overall response rate was 61%, the median time to PR was 8.0 months. Six patients achieved stable disease, although three developed progressions. Of the six patients with a PR, the median change in maximum diameter was -46%, and the median change in maximum volume was -84%. Three patients could have been diagnosed with progression at least 6 months earlier if the AV increment was considered. An AV assessment is essential for an accurate response assessment of DTs and radiotherapy seems feasible as a first-line treatment for DTs.

View Abstract