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The Desmoid Tumor Research Foundation

August 2017

Papillary thyroid carcinoma with desmoid-type fibromatosis: A clinical, pathological, and immunohistochemical study of 14 cases

Author Information

Takada N(1), Hirokawa M(2), Ito M(3), Ito A(1), Suzuki A(1), Higuchi M(1), Kuma S(2), Hayashi T(2), Kishikawa M(4), Horikawa S(5), Miyauchi A(6)

(1)Department of Clinical Laboratory, Kuma Hospital, Kobe, Japan.(2)Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan.(3)Department of Pathology, Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Omura, Japan.(4)Nagasaki Diagnostic Pathology Clinic, Nagasaki, Japan.(5)Department of Surgery, Nagasaki Kamigoto Hospital, Minamimatsuura, Japan.(6)Department of Surgery, Kuma Hospital, Kobe, Kuma Hospital, Japan.

Publication

Endocr J

Summary

Papillary thyroid carcinoma (PTC) with desmoid-type fibromatosis (DTF) is characterized by genetic alterations of the fibroblasts. This report aims to describe the clinical, pathological, and immunohistochemical findings in 14 cases of PTC-DTF and to clarify the diagnostic significance of the variant. The patients included 9 women and 5 men, with a mean age of 49.3 years. PTCs with focal DTF components and with extensive DTF components included 7 cases each. On aspiration cytology, 12 cases were reported as suspicious for malignancy or malignant, and schwannoma or fibroma was suggested in 1 case each. The DTF components were histologically classified into 4 types, namely, central (4 cases), peripheral (1 case), mixed (7 cases), and diffuse type (2 cases). The stromal components were consistent with those of DTF. Immunohistochemically, fibroblasts in the DTF components showed nuclear and cytoplasmic expression for beta-catenin in 12 cases. We agree that PTC with nodular fasciitis-like stroma should be renamed to PTC-DTF.

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