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The Desmoid Tumor Research Foundation

June 2017

Human microRNA expression in sporadic and FAP-associated desmoid tumors and correlation with beta-catenin mutations.

Author Information

Aldo Cavallini,Catia Lippolis,Claudia Covelli,Domenico Piscitelli,Donato Francesco Altomare,Maria Teresa Rotelli,Matteo Accetturo,Nicola Carella,Rosa Digennaro

General Surgery and Liver Transplantation Unit, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", Bari, Italy.,Laboratory of Cellular and Molecular Biology, National Institute for Digestive Diseases, IRCCS "Saverio de Bellis", Castellana Grotte, Bari, Italy.,Nephrology Unit, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", Bari, Italy.,Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari " Aldo Moro", Bari, Italy.

Publication

Summary

DTs can occur sporadically or associated with the familial adenomatous polyposis coli (FAP). Most sporadic DTs are associated with β-catenin gene (CTNNB1) mutations, while mutated APC gene causes FAP disease. microRNAs (miRNAs) are involved in many human carcinogenesis.

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