The Desmoid Tumor Research Foundation

June 2026

Spindle Cell Fibromatosis of the Breast: A Lesson in Malignancy Mimicry

Author Information

Valerie Fiore 1, Marc Knezevic-Maragh 2, Jovia Williams 2, Caleb Bonsu 2, Oluwatito Roberts 2, Sharon Koehler 1

1Department of Surgery Episcopal Health Services New York New York USA. 2Department of Medicine Ross University School of Medicine Miramar Florida USA.

Publication

Clin Case Rep

Summary

Spindle cell fibromatosis of the breast (SCFB) is a rare benign tumor that closely mimics malignancy on imaging and clinical examination. Accurate diagnosis relies on histopathology and immunohistochemistry, particularly β-catenin staining, to guide appropriate management and avoid overtreatment while addressing its locally aggressive behavior and associated conditions.

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