RECIST (Response Evaluation Criteria in Solid Tumors)

Response Evaluation Criteria in Solid Tumors (RECIST) is “a standard way to measure how well a cancer patient responds to treatment. It is based on whether tumors shrink, stay the same, or get bigger. To use RECIST, there must be at least one tumor that can be measured on x-rays, CT scans, or MRI scans. The types of response a patient can have are a complete response (CR), a partial response (PR), progressive disease (PD), and stable disease (SD).” (Source: National Cancer Institute)

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Learn about the DTRF Radiomics Working Group RECIST is currently required by the FDA in clinical trials to assess if a tumor is progressing, stable, or responding to treatment, RECIST is strictly measurement-based and does not factor in other positive indicators that do not involve changes in tumor size. Additionally, RECIST relies on certain measurements to monitor response — such as “longest dimension” — which may not accurately reflect the typical response of desmoid tumors to treatments. The DTRF Radiomics Working Group[link to “Radiology Working Group” page] is addressing this issue and defining other imaging features beyond RECIST that can be used to better evaluate desmoid tumor patient outcomes.

“Cancer that has recurred (come back), usually after a period of time during which the cancer could not be detected. Also called recurrent cancer.” (Source: National Cancer Institute) Recurrence can come after a therapeutic, non-surgical or surgical intervention.

For more information on recurrence in desmoid tumors, please read the Global Consensus Paper on Desmoid Tumor Treatment.

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Cancer that does not respond to treatment. The cancer may be resistant at the beginning of treatment or it may become resistant during treatment. Also called resistant cancer. (Source: National Cancer Institute)

“Surgery to remove tissue or part or all of an organ.” (Source: National Cancer Institute)

For more information on surgery in desmoid tumors, please read the Global Consensus Paper on Desmoid Tumor Treatment.

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A type of cancer that begins in bone or in the soft tissues of the body, including cartilage, fat, muscle, blood vessels, fibrous tissue, or other connective or supportive tissue. Different types of sarcoma are based on where the cancer forms. For example, osteosarcoma forms in bone, liposarcoma forms in fat, and rhabdomyosarcoma forms in muscle. Treatment and prognosis depend on the type and grade of the cancer (how abnormal the cancer cells look under a microscope and how quickly the cancer is likely to grow and spread). Sarcoma occurs in both adults and children. (Source: National Cancer Institute)

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“In medicine, the opinion of a doctor other than the patient’s current doctor. The second doctor reviews the patient’s medical records and gives an opinion about the patient’s health problem and how it should be treated. A second opinion may confirm or question the first doctor’s diagnosis and treatment plan, give more information about the patient’s disease or condition, and offer other treatment options.” (Source: National Cancer Institute)

For more information on second opinions and desmoid tumors, please watch our 2022 video “Getting the Most Out of Your Consultation and Treatment Plan with Dr. Candace Haddox.”

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Learn About Diagnosis of Desmoid Tumors