Aggressive fibromatosis-associated with papillary thyroid cancer: two cases and a brief review

Summary

Herein, we report two cases of aggressive fibromatosis (AF) arising in the neck that were associated with papillary thyroid cancer. One is a 31-year-old male patient who was diagnosed with AF 9 months after his thyroid cancer operation; there has been no recurrence after surgical resection and postoperative radiotherapy. The other is a 53-year-old female patient who was diagnosed with thyroid cancer and AF simultaneously. There is still no recurrence after surgical resection, endocrine therapy and thyroid-stimulating hormone (TSH) suppression treatment. Both cases showed beta-catenin positivity upon further immunohistochemistry (IHC) examination. The treatment strategy in this situation includes surgical excision combination with radiotherapy and endocrine therapy to reduce the recurrence rate.