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The Desmoid Tumor Research Foundation

March 2016

Chest wall desmoid tumours treated with definitive radiotherapy: a plan comparison of 3D conformal radiotherapy, intensity-modulated radiotherapy and volumetric-modulated arc radiotherapy.

Author Information

Angela Hong,Diana Ng,James Lee,Jia Liu,Paul Stalley

Central Clinical School, Faculty of Medicine, University of Sydney, Camperdown, NSW, Australia. angela.hong@sydney.edu.au.,Central Clinical School, Faculty of Medicine, University of Sydney, Camperdown, NSW, Australia. jia.liu@unsw.edu.au.,Central Clinical School, Faculty of Medicine, University of Sydney, Camperdown, NSW, Australia. pdstalley@optusnet.com.au.,Department of Radiation Oncology, Mater Hospital, Genesis Cancer Care, St Leonards, NSW, Australia. Diana.Ng@cancer.com.au.,Department of Radiation Oncology, Mater Hospital, Genesis Cancer Care, St Leonards, NSW, Australia. James.Lee@cancer.com.au.

Publication

Summary

Definitive radiotherapy is often used for chest wall desmoid tumours due to size or anatomical location. The delivery of radiotherapy is challenging due to the large size and constraints of normal surrounding structures. We compared the dosimetry of 3D conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc radiotherapy (VMAT) to evaluate the best treatment option.For inoperable chest wall desmoid tumours, VMAT delivered equivalent target coverage when compared to IMRT but required 60 % less MU. Both VMAT and IMRT were superior to 3DCRT in terms of better PTV coverage and sparing of lung tissue.

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