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The Desmoid Tumor Research Foundation

January 2016

Clinical significance of midkine expression in sporadic desmoid tumors.

Author Information

Hee Sung Kim,Jin Kim,Kyung Han Nam,Woo Ho Kim

Cancer Research Institute, College of Medicine, Seoul National University, Seoul 110-799, Republic of Korea.,Cancer Research Institute, College of Medicine, Seoul National University, Seoul 110-799, Republic of Korea; Department of Pathology, College of Medicine, Seoul National University, Seoul 110-799, Republic of Korea.,Department of Pathology, College of Medicine, Chung-Ang University, Seoul 156-755, Republic of Korea.,Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 612-896, Republic of Korea.

Publication

Summary

The aim of the present study was to identify the prognostic factors for the propensity for recurrence in sporadic desmoid tumors. The catenin (cadherin-associated protein) β1 (CTNNB1) genotypes and expression of Wnt pathway proteins and midkine (also termed neurite growth-promoting factor 2) were investigated in 159 patients with sporadic desmoid tumors. The multivariate analysis of recurrence demonstrated that an extra-abdominal tumor site [hazard ratio (HR), 2.625; P=0.001] and midkine expression (HR, 2.077; P<0.009) were independent prognostic factors of tumor recurrence. In conclusion, the present results suggest that the tumor site and midkine expression may be predictive markers for the recurrence of sporadic desmoid tumors.

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