The Desmoid Tumor Research Foundation

August 2020

Cryoablation of Extra-Abdominal Desmoid Tumors: A Single-Center Experience with Literature Review

Author Information

Saltiel S(1), Bize PE(2), Goetti P(3), Gallusser N(3), Cherix S(3), Denys A(1), Becce F(1), Tsoumakidou G(1).

(1)Dept of Diagnostic & Interventional Radiology, Lausanne Univ Hosp & Univ of Lausanne, Lausanne, SW. (2)Dept of Radiology, Clinique de Genolier, Genolier, SW. (3)Dept of Orthopaedics & Traumatology, Lausanne Univ Hosp & Univ of Lausanne, Lausanne, SW.

Publication

Diagnostics (Basel)

Summary

Cryoablation (CA) has gained popularity in the treatment of benign and malignant musculoskeletal tumors. While extra-abdominal desmoid (EAD) tumors are not malignant, they remain challenging to treat because of their high local recurrence rate. We reviewed all EAD tumors treated with CA at our institution between November 2012 and March 2020. Fourteen procedures were performed on nine females and one male (mean age, 33 ± 18 years) as either first-line (n = 4) or salvage therapy (n = 6) with curative intent (n = 8) or tumor debulking (n = 2). Treatment outcome was based on the change in enhanced tumor volume (ET-V). For curatively treated patients, the mean ET-V change was -97 ± 7%, -44 ± 143%, and +103 ± 312% at 3, 6, and 12 months, respectively. For debulking patients, the mean ET-V change was -98 ± 4%, +149 ± 364%, and +192 ± 353% at 3, 6, and 12 months, respectively. During a mean follow-up of 53.7 months (range, 12-83 months), one grade III and one grade IV complication were noted.

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