The Desmoid Tumor Research Foundation

August 2026

Cryoablation of Malignancies and Aggressive Benign Diseases in Children: Proceedings from the Society of Interventional Radiology Foundation Research Consensus Panel

Author Information

Eric J Monroe 1, Shankar S Rajeswaran 2, Lindsay J Talbot 3, Michael J Temple 4, Vandana Batra 5, K F Kevin Fung 6, Raja Shaikh 7, Nadine Abi-Jaoudeh 8, Anne Marie Cahill 9

1Department of Radiology, University of Wisconsin, Madison, Wisconsin. Electronic address: emonroe@uwhealth.org. 2Department of Radiology, Lurie Children's Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 3Department of Surgery, Memphis, Tennessee. 4Department of Radiology, St. Jude Children's Research Hospital, Memphis, Tennessee. 5Department of Pediatrics, Philadelphia, Pennsylvania. 6Department of Radiology, Hong Kong Children's Hospital, Hong Kong. 7Department of Radiology, Boston Children's Hospital, Boston, Massachusetts. 8Department of Radiology, University of California-Irvine, Orange, California. 9Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Publication

J Vasc Interv Radiol

Summary

While literature surrounding pediatric applications of cryoablation continues to grow and demonstrate potential benefits, evidence to date largely comprises small, retrospective, and uncontrolled series. To address this opportunity, a multidisciplinary panel of pediatric specialists convened virtually in a research consensus panel organized by the Society of Interventional Radiology (SIR); each panelist presented current data surrounding common applications of cryoablation in the pediatric population. A recurring theme throughout the discussion was the potential for cryoablation to increase quality of life in pediatric patients whether applied with curative or palliative intent. After presentations and discussions, research concepts were discussed and ranked on their potential impact, with the following 3 topics emerging as top priorities: (a) thoracic event-free survival and complication comparison between pulmonary metastasectomy and cryoablation of lesions amenable to either modality, (b) a prospective comparison of systemic therapy and cryoablation versus systemic therapy alone in the treatment of desmoid tumor, and (c) the biologic effects of cryoablation on healthy bone, cartilage, and growth plates as may be affected in the treatment of benign osseous lesions.

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