Hospices Civils de Lyon, Lyon, France. email@example.com
We report the consecutive cases of two patients who had multiple recurrences of locally advanced desmoid tumors and for whom treatment with combined medical and surgical approaches had failed. Both patients then had a major objective response to treatment with a combination of celecoxib and sorafenib. The outcomes for these two patients provide potential equipoise for controlled studies of the celecoxib_sorafenib combination in patients with refractory desmoid disease associated with familial adenomatous polyposis.