The Desmoid Tumor Research Foundation

October 2025

Desmoid Tumors-Experience from a Referral Center, Part 1: Multidisciplinary Review and Practical Recommendations

Author Information

Alvarez Alvarez Rosa 1, Agra Pujol Carolina 2, Arregui Valles Marta 1, Alijo Francisco 3, Fernández Gonzalo Adriana 3, Gutiérrez Natalia 1, Lozano Lominchar Pablo 4, Mata Fernández Cristina 5, Mediavilla Santos Lidia 6, Novo Ulrike 3, Santos Marina 7, Hernández Torrado Guillermo 1, Carpintero García Henar 6, Gutiérrez-Ortiz de la Tabla Ana 8

1Medical Oncology Department, Instituto de Investigacion Sanitaria Gregorio Marañon, Hospital General Universitario Gregorio Marañon, 28007 Madrid, Spain. 2Department of Pathology, Hospital Gregorio Marañon, Complutense University, 28007 Madrid, Spain. 3Radiology Department, Hospital General Universitario Gregorio Marañon, 28007 Madrid, Spain. 4General Surgery and Surgical Oncology Department, Hospital Universitario Gregorio Marañon, Complutense University, 28007 Madrid, Spain. 5Pediatric and Adolescent Oncohematology Unit, Pediatric Sarcomas National Reference Center, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain. 6Orthopedic Surgery and Traumatology Department, Musculoskeletal Oncology Section, Hospital Universitario Gregorio Marañon, 28007 Madrid, Spain. 7Radiation Oncology Department, Hospital Universitario Gregorio Marañon, 28007 Madrid, Spain. 8Medical Oncology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain.

Publication

Cancers (Basel)

Summary

Desmoid tumors (DTs), also known as aggressive fibromatosis, are rare neoplasms characterized by local invasiveness and a high risk of recurrence, despite their lack of metastatic potential. The management of these tumors remains challenging due to their unpredictable behavior and heterogeneous presentations. In this two-part study, we first provide a comprehensive review of the scientific evidence on diagnosis and emerging therapeutic strategies for DT. In the second part, we will present a retrospective analysis of our experience at a national reference center for sarcoma treatment, focusing on diagnostic strategies, therapeutic interventions, and clinical outcomes.

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