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The Desmoid Tumor Research Foundation

May 2020

Desmoid Type Fibromatosis of the Breast: Ten-Year Institutional Results of Imaging, Histopathology, and Surgery [Full Article]

Author Information

Lorenzen J(1), Cramer M(1), Buck N(1), Friedrichs K(2), Graubner K(3), Luhr CS(4), Lindner C(3), Niendorf A(4).

(1)Radiologische Allianz, Hamburg, Germany. (2)Mammazentrum Hamburg, Hamburg, Germany. (3)Dept of Gynecology and Obstetrics, Agaplesion Diakonieklinikum Hamburg, Hamburg, Germany. (4)MVZ Pathologie Hamburg-West, Hamburg, Germany.

Publication

Breast Care (Basel)

Summary

A total of 14 women and 1 man underwent surgery on desmoid type fibromatosis of the breast. The average patient age was 49 years (range: 22-72 years). The mean tumor size was 2.2 cm (range: 0.8-4.2 cm). The tumor was detectable in mammography in 12 out of 13 patients and in all 15 patients in sonography. MRI was performed preoperatively in 6 patients; in all of the patients, the tumor was visualized with inhomogeneous contrast enhancement. In the imaging procedures, all desmoid type fibromatoses were classified as suspicious. Performing the core biopsy, preoperative histology confirmed desmoid fibromatosis in 12 out of 15 patients. Nuclear stain for beta-catenin was positive in 7 out of 10 patients. Negative staining was found for AE1/A3 in 10 out of 10 and CD34 in 12 out of 12 patients. In all of the patients, a single-stage operation without the detection of border-forming tumor margins was performed. The follow-up interval ranged from 16 to 96 months (mean: 44.86 months, median: 43 months). In this follow-up period, no patient was diagnosed with desmoid tumor recurrence. In imaging, desmoid type fibromatosis of the breast has typical malignancy-related criteria. Extensive preoperative diagnostics enable the planning of complete primary excision of the lesion and reduce the recurrence risk.

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