Bastiaan B J Tops,Paul J van Diest,Pieter J Slootweg,Uta Flucke
Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Desmoid-type fibromatosis (desmoid) is a locally aggressive (myo)fibroblastic lesion. It represents one of the more common fibrous tumours in children and adolescents. The head and neck region is more often involved than in adults. Our study provides evidence of genetic similarities in desmoid and desmoplastic fibroma. Additionally, we expanded the spectrum of mutations in CTNNB1 with one novel desmoid mutation.