Final days to save 20% off DTRF "Together We Will" Weekend tickets. - Register today!

The Desmoid Tumor Research Foundation

May 2020

Does ileoanal pouch surgery increase the risk of desmoid in patients with familial adenomatous polyposis?

Author Information

Xie M(1)(2), Chen Y(1), Wei W(3), He X(1), Li X(1)(2), Lian L(1)(2), Lan P(1)(2).

(1)Dept of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen Univ, Guangzhou, Guangdong, China. (2)Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen Univ, Guangzhou, Guangdong, China. (3)Dept of General Surgery, The People's Hospital of Gaozhou, Gaozhou, Guangdong, China.

Publication

Int J Colorectal Dis

Summary

Patients with familial adenomatous polyposis (FAP) may undergo either ileorectal anastomosis (IRA) or ileal pouch anal anastomosis (IPAA) depending on the degree of rectal involvement. Desmoid tumors (DTs) may arise postoperatively. Whether IPAA is associated with a higher risk of DTs as compared with IRA remains controversial. The purpose of this study was to determine whether IPAA increased the risk of DTs by analyzing the published data that compared IRA and IPAA as the primary treatment for FAP. A metaanalysis was performed to analyze the published data between 1989 and 2019. IRA and IPAA were compared with respect to the incidence of DTs. Eight retrospective studies with a total of 1072 patients were identified: 491 underwent IPAA and 581 IRA. There was no significant difference in the incidence of DTs between IPAA and IRA (11.81% vs. 9.47%, OR 0.95, P?=?0.85). Meanwhile, the overall complication (42.97% vs. 36.76%, OR 1.32, P?=?0.11), incidence of cancer (4.88% vs. 8.37%, OR 0.28, P?=?0.26), and overall mortality (0.33% vs. 5.20%, OR 0.49, P?=?0.53) were comparable too. Ileoanal pouch surgery is associated with similar risk of desmoid in patients with FAP after surgery.

View Abstract