The Desmoid Tumor Research Foundation

September 2017

Effect of surgical margins on prognosis in aggressive fibromatosis: A single-institutional analysis of 90 patients

Author Information

Harati K(1), Jaenisch A(1), Behr B(1), Goertz O(1), Harati A(2), Hirsch T(1), Stricker I(3), Lehnhardt M(1), Daigeler A(1)

(1)Department of Plastic Surgery, BG-University Hospital Bergmannsheil, D-44789 Bochum, Germany.(2)Department of Neurosurgery, Klinikum Dortmund, D-44145 Dortmund, Germany.(3)Institute of Pathology, Ruhr-University Bochum, D-44789 Bochum, Germany.

Publication

Oncol Lett

Summary

The present retrospective analysis aimed to determine prognostic factors leading to recurrence. Between 2000 and 2014, 114 patients with aggressive fibromatosis were treated surgically at BG-University Hospital Bergmannsheil (Bochum, Germany). The rates of recurrence-free survival (RFS) after 5 years were 68.8% [95% confidence interval (CI), 53.5-79.9%] in patients with R0-resected primary tumors and 34.1% (95% CI, 19.9-48.9%) in patients with R1/R2-status (P=0.001). The current results suggest that the attainment of microscopically negative surgical margins at the initial surgical treatment is associated with a significantly improved prognosis.

View Abstract