The Desmoid Tumor Research Foundation

February 2019

Estrogen receptor beta expression correlates with proliferation in desmoid tumors

Author Information

Santti K(1), Ihalainen H(1)(2), Rönty M(3), Karlsson C(4), Haglund C(5)(6), Sampo M(3), Tarkkanen M(1), Blomqvist C(1)(7).

(1)Dept of Oncology, Comprehensive Cancer Center, Helsinki Univ Hospital and Univ of Helsinki, Helsinki, Finland. (2)Dept of Plastic Surgery, Helsinki Univ Hospital and Univ of Helsinki, Helsinki, Finland. (3)Dept of Pathology, HUSLAB and Univ of Helsinki, Helsinki, Finland.(4)Dept of Medical Diagnostics, School of Health Sciences, Orebro Univ, Orebro, Sweden. (5)Dept of Surgery, Helsinki Univ Hospital and Univ of Helsinki, Helsinki, Finland. (6)Translational Cancer Biology, Reseach Programs Unit, Univ of Helsinki, Helsinki, Finland. (7)Dept of Oncology, Orebro Univ Hospital, Orebro, Sweden.

Publication

J Surg Oncol

Summary

Estrogen receptor signaling and cyclin D1 have a major role in tumor cell proliferation in breast cancer. Desmoid tumors are rare neoplasms that may respond to endocrine treatment. The present study aimed to investigate the expression levels and the clinical relevance of estrogen receptor beta (ERB) and cyclin D1 in desmoid tumors. This study consists of 83 patients with a surgically treated desmoid tumor. ERB and cyclin D1 expression was examined by immunohistochemistry in tissue microarrays. Cyclin A and Ki67 were studied in our previous work. Median ERB expression was 10.8%. ERB expression correlated with expression of the proliferation antigens Ki67 (rp ?=?0.35, P?=?0.003), cyclin D1 (rp ?=?0.34, P?=?0.004), and cyclin A (rp ?=?0.34, P?=?0.004). ERB immunoexpression showed a trend towards predictive impact for recurrence as a continuous variable. Further explorative analysis indicated that very high ERB expression was related to high risk of relapse (hazard ratio [HR] 2.6; P?=?0.02). Median cyclin D1 expression was 15.6%. High cyclin D1 expression was associated with high Ki67 and cyclin A expression. Cyclin D1 was not associated with time to recurrence. ERB and cyclin D1 immunopositivity correlated with high proliferation in desmoid tumors. High ERB expression might be predictive for postoperative recurrence.

View Abstract