Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity.
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Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity.
Author Information
Amy P N Skubitz,Benjamin S Misemer,Christopher L Corless,Edward Y Cheng,J Carlos Manivel,Jonathan C Henriksen,Joseph S Koopmeiners,Keith M Skubitz,Stephen C Schmechel
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota; Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota.
Publication
Summary
Aggressive fibromatosis (AF) represents a group of tumors with a variable and unpredictable clinical course, characterized by a monoclonal proliferation of myofibroblastic cells. Identification and validation of genes whose expression patterns are associated with AF may elucidate biological mechanisms in AF, and aid treatment selection. This study was designed to examine the protein expression by immunohistochemistry (IHC) of four genes, ADAM12, FAP, SOX11, and WISP1, that were found in an earlier study to be uniquely overexpressed in AF compared with normal tissues.
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