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The Desmoid Tumor Research Foundation

September 2023

Extra‑abdominal recurrent aggressive fibromatosis: A case series and a literature review

Author Information

Saywan K Asaad 1 2, Ari M Abdullah 1 3, Shkar Ali Abdalrahman 4, Fattah H Fattah 1 2, Soran H Tahir 1 2, Choman Sabah Omer 1, Rezheen J Rashid 1 5, Marwan N Hassan 1 6, Shvan H Mohammed 6, Fahmi H Kakamad 1 2 6, Berun A Abdalla 1 6

1Department of Scientific Affairs, Smart Health Tower, Sulaimani, Kurdistan 46001, Iraq. 2College of Medicine, University of Sulaimani, Sulaimani, Kurdistan 46001, Iraq. 3Sulaimani Teaching Hospital, Sulaimani, Kurdistan 46001, Iraq. 4Department of Surgery, Shar Hospital, Sulaimani, Kurdistan 46001, Iraq. 5Department of Radiology, Hiwa Hospital, Sulaimani, Kurdistan 46001, Iraq. 6Kscien Organization, Hamdi Str, Azadi Mall, Sulaimani, Kurdistan 46001, Iraq.

Publication

Mol Clin Oncol

Summary

Aggressive fibromatosis is a rare clonal proliferative tumor arising from mesenchymal cells in the fascia and musculoaponeurotic structures. The aim of the present study was to describe several cases of extra-abdominal recurrent aggressive fibromatosis. The present study was a single-center retrospective case series of patients with recurrent aggressive fibromatosis. The cases were managed at a single private facility. A total of 9 patients with recurrent fibromatosis were included. The mean and median ages of the patients were 29 and 30 years, respectively. In total, two thirds (66.67%) of the cases were female. A negative previous medical history was reported in 7 cases (77.7%), and diabetes and hypertension were reported in 1 case (11.1%). Overall, only 1 case (11.1%) had a family history of breast fibromatosis. The time interval between primary tumor resection and recurrent presentation was 28 months. In 6 cases (66.7%), the tumor was located in the extremities. Pain was the most common presenting symptom in 6 cases (66.7%). All patients had their recurring tumor surgically removed, followed by radiation in 5 cases. The resection margin was positive in 4 cases (44.4%). Each patient was subjected to a careful three-month follow-up for recurrences. On the whole, the present study demonstrates that despite the fact that several therapeutic approaches for extra-abdominal recurrent aggressive fibromatosis have been described in the literature, there is a significant likelihood of recurrence following resection.

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