The Desmoid Tumor Research Foundation

July 2017

Gastric tumours in FAP

Author Information

Walton SJ(1)(2), Frayling IM(3), Clark SK(4)(5), Latchford A(4)(5)

(1)The Polyposis Registry, St Mark's Hospital, Watford Road, Harrow, London, UK.(2)Department of Surgery and Cancer, Imperial College London, Harrow, London, UK. (3)Institute of Cancer and Genetics, Cardiff University, Harrow, London, UK.(4)The Polyposis Registry, St Mark's Hospital, Watford Road, Harrow, London, UK.(5)Department of Surgery and Cancer, Imperial College London, Harrow, London, UK.

Publication

Fam Cancer

Summary

Gastric cancer is not a recognised extra-colonic manifestation of FAP, except in countries with a high prevalence of gastric cancer. Data regarding gastric adenomas in FAP are sparse. The aim of this study was to review the clinical characteristics of gastric tumours occurring within an FAP population from the largest European polyposis registry. An association between gastric tumour and desmoid development was observed; 7/8 (88%) cancer and 11/21 (52%) adenoma cases had a personal or family history of desmoid. It would appear from this small, retrospective study that gastric cancer is not a prominent extra-colonic feature of FAP in the Western world. There may be an association between gastric tumour and desmoid occurrence but a large multicentre cohort is necessary to investigate this further.

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