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The Desmoid Tumor Research Foundation

February 2017

Long-term Efficacy of Methotrexate Plus Vinblastine/Vinorelbine in a Large Series of Patients Affected by Desmoid-Type Fibromatosis.

Author Information

Alessandra Casale,Alessandro Gronchi,Anna Maria Frezza,Antonella Messina,Carlo Morosi,Chiara Colombo,Elena Palassini,Luca Lalli,Luigi Mariani,Marco Fiore,Paola Collini,Paolo Giovanni Casali,Silvia Stacchiotti

From the Departments of *Medical Oncology, †Statistics, and ‡Surgery, IRCCS Fondazione Istituto Nazionale Tumori; §Department of Medical Oncology, Humanitas Cancer Center, IRCCS; and Departments of ∥Radiology and ¶Pathology, IRCCS Fondazione Istituto Nazionale Tumori, Milan, Italy.

Publication

Summary

We retrospectively reviewed data from all adult patients with sporadic desmoid-type fibromatosis treated with MTX and vinca alkaloids at our institution between 1989 and 2014. In this series, chemotherapy with MTX and vinca alkaloids is confirmed to be active and effective, with a remarkable PFS, higher in responding patients, and limited toxicity. Even progression can be successfully rechallenged.

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