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The Desmoid Tumor Research Foundation

December 2019

PARP-1 expression as a prognostic factor in Desmoid-type fibromatosis

Author Information

Brautigam K(1), Lindner J(2), Budczies J(3), Pahl S(4), Kunitz A(5), Melcher I(6), Wust P(7), Nebrig M(8), Baur A(9), Denkert C(10), Pfitzner B(11).

(1)Inst of Pathology, Univ of Bern, Bern, CH. (2)Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, & Berlin Inst of Health, Inst of Pathology, Berlin, DE; DKTK, DKFZ Heidelberg, Heidelberg, DE. (3)Inst of Pathology, Univ Hosp Heidelberg, Heidelberg, DE. (4)Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, & Berlin Inst of Health, Inst of Pathology, Berlin, DE. (5)Vivantes Klinikum Sp&au, Dept of Hematology, Oncology & Palliative Medicine, Berlin, DE. (6)Vivantes Klinikum Sp&au, Dept of Orthopaedics & Trauma Surg, Berlin, DE. (7)Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, & Berlin Inst of Health, Dept of Radiation Oncology & Radiotherapy, Berlin, DE. (8)Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, & Berlin Inst of Health, Dept of Surg, Berlin, DE. (9)Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universit„t zu Berlin, & Berlin Inst of Health, Dept of Rad, Berlin, DE; Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, & Berlin Inst of Health, Dept of Nuclear Medicine, Berlin, DE. (10)Dept of Pathology, Univ Hosp Marburg, Philipps-Universitat, Marburg, DE. (11)Inst of Pathology, DRK Kliniken Berlin Westend, Berlin, DE.

Publication

Ann Diagn Pathol

Summary

In this study, we investigated the expression of estrogen receptors (ER) alpha (1) and beta (2), progesterone receptor (PR), androgen receptor (AR), as well as Poly Adenosine Diphosphate Ribose Polymerase-1 (PARP-1) via immunohistochemistry and quantitative RT-PCR in 69 tissue samples of desmoid tumors. Immunohistochemistry was quantified using the Immunoreactivity Score (IRS). Overall expression patterns were correlated with clinical-pathologic parameters to determine their value as a prognostic factor. Among the investigated hormone receptors only ER Beta showed partial cytoplasmic reactivity. PARP-1 revealed variable nuclear positivity with IRS ranging from 0 to 6. Univariate survival analysis showed that higher expression of estrogen receptor 1 was associated with shorter disease-free survival (p?=?0.005). Uni- (p?=?0.03) and multivariate (p?=?0.003) analyses of mRNA data revealed that higher PARP-1 expression correlated with earlier recurrence. According to this study PARP-1 expression is associated with poorer prognosis, that is faster recurrence, highlighting the possibility of PARP-1-targeting agents as a therapeutic option. Hormone receptors were of minor prognostic relevance in this study.

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