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The Desmoid Tumor Research Foundation

September 2019

Periosteal Reaction Possibly Induced by Pazopanib: A Case Report and Literature Review

Author Information

Hosokawa T(1), Hara T(2), Arakawa Y(3), Oguma E(1), Yamada Y(4).

(1)Dept of Radiology, Saitama ChildrenÂ’s Medical Center, Saitama. (2)Dept of Gastroenterology and Hepatology, Saitama ChildrenÂ’s Medical Center, Saitama. (3)Dept of Hematology/Oncology, Saitama ChildrenÂ’s Medical Center, Saitama. (4)Dept of Radiology, Keio Univ School of Medicine, Tokyo, Japan.

Publication

J Ped Hem/Onc

Summary

Although complications associated with pazopanib, a multitarget tyrosine kinase inhibitor, are known, periosteal reaction as a side effect has never been reported. We present a case involving a male pediatric patient with desmoid tumors treated for 6 months with pazopanib who presented with pain and periosteal reaction in the ilium and scapula. Three months after termination of pazopanib therapy, the periosteal reaction in the scapula resolved and that in the ilium improved. Children receiving pazopanib presenting with focal pain should be examined for the periosteal reaction; this knowledge may facilitate correct diagnosis of symptoms as a drug-associated finding.

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