Prognostic Factors for Local Recurrence after Cryoablation of Desmoid Tumors.

Summary

PURPOSE: This study aimed to determine the risk factors for local of adult patients treated for desmoid tumors by cryoablation. MATERIAL AND METHODS: Eighty-four patients treated for non-abdominopelvic desmoid tumors by cryoablation from July 2012 to July 2020 were included in a retrospective study. The population was composed of 64 women (76.19%) and 20 men (23.81%), aged from 16 to 75 years (median = 35 ± 14.25 years). Each patient had a pre procedural gadolinium enhanced MRI and was followed up to 36 months with the same technic. Clinical features, such as tumor size and previous treatment, epidemiological features, and the technical parameters of cryoablation were studied. RESULTS: Local relapse was found for 19/84 patients (22.62%). The 12-, 24-, and 36-month progression free survival (PFS) was 89% (95%CI [79 to 94]), 74% (95%CI [60 to 83]), and 68% (95%CI [53 to 79]), respectively.In univariate analysis, significant prognostic factors associated with local recurrence were: non-abdominal wall location (p = 0.042), a debulking strategy (p = 0.0105), a risk of visceral injury (p = 0.034) or peripheral nerve injury during cryoablation (p = 0.033), previous radiation therapy (p = 0.043) and treatment before 2016 (p = 0.008).At multivariate analysis, abdominal wall tumors displayed the best outcome, whereas the neck and trunk showed a high rate of recurrence (HR 7.307 [1.396-38.261]). CONCLUSION: The local recurrence of desmoid tumors after cryoablation depends on a number of prognostic factors, in particular, a non-abdominal wall location of the tumor and previous local treatment such as surgery or radiation therapy.