Dept of Orthopedics, West China Hospital, Sichuan Univ, Chengdu, Sichuan, PR China.
Drug Des Devel Ther
As targeted therapy, tyrosine kinase inhibitors have been recently reported to contribute to the treatment of desmoid fibromatosis (DF). Thus, the purpose of this study was to assess the efficacy and safety of anlotinib, a novel multi-kinase angiogenesis inhibitor, in patients with DF. We retrospectively collected the clinical medical records of patients with extremity DF who received anlotinib between January 2019 and January 2020 in our center. Anlotinib was started with a dose of 8 mg daily and adjusted according to the drug-related toxicity. In total, 21 (6 male, 15 female) consecutive patients with DF were enrolled. None of the patients achieved a complete response, but eight (38.1%) patients achieved a partial response and ten patients (47.6%) achieved disease stability. Three (14%) patients developed progressive disease and the 3-, 6-, and 12-month PFS rates were 95.2%, 90.5%, and 84.0%, respectively. The disease control rate was 86.0% (18/21) and the objective response rate was 38.1% (8/21). Moreover, 15/21 (71.4%) patients achieved a reduction in tumor size, accompanied with a decrease in T2-weighted signal intensity on magnetic resonance imaging and clinical benefit. Anlotinib was effective against DF with an acceptable safety profile, and significantly slowed the disease progression.